Version July 2025
Note: Prior to treatment WBC should be >4,000/mm3, ANC >2,000/mm3, and platelets >100,000/mm3.
Colorectal cancer, advanced: IV: 3 mg/m2 once every 3 weeks in the absence of toxicity.
Malignant pleural mesothelioma, advanced (off-label use): IV: 3 mg/m2 once every 3 weeks (in combination with cisplatin) until disease progression or unacceptable toxicity occurs (Ref).
Dosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.
CrCl >65 mL/minute: No dosage adjustment necessary.
CrCl 55 to 65 mL/minute: Reduce dose to 75% of usual dose once every 4 weeks.
CrCl 25 to 54 mL/minute: Reduce dose to percentage of dose equivalent to CrCl once every 4 weeks (eg, reduce dose to 25% of usual dose for CrCl of 25 mL/minute)
CrCl <25 mL/minute: Do not administer (use is contraindicated in severe renal impairment)
Preexisting impairment: Use is not recommended in clinical jaundice or decompensated liver disease.
Mild to moderate impairment: No dosage adjustment necessary; use with caution.
Severe impairment: Use is contraindicated.
Hepatotoxicity during treatment: Interrupt raltitrexed until hepatic enzymes return to grade 2 or lower.
American Society of Clinical Oncology guidelines for appropriate systemic therapy dosing in adults with cancer with a BMI ≥30 kg/m2 : Utilize patient's actual body weight for calculation of BSA- or weight-based dosing; manage regimen-related toxicities in the same manner as for patients with a BMI <30 kg/m2; if a dose reduction is utilized due to toxicity, may consider resumption of full, weight-based dosing (or previously tolerated dose level) with subsequent cycles only if dose escalations are allowed in the prescribing information, if contributing underlying factors (eg, hepatic or kidney impairment) are sufficiently resolved, AND if performance status has markedly improved or is considered adequate (Ref). Note: Once a dose reduction is made for some toxicities, the manufacturer recommends all subsequent dosing be administered at that reduced dosing level; refer to prescribing information for further information.
Delay dose in subsequent cycles until recovery from toxicity. May consider administering leucovorin if appropriate. Once a dose reduction has been made, do not escalate dose in subsequent cycles.
Grade 4 GI toxicity (diarrhea or mucositis) or grade 3 GI toxicity in combination with grade 4 hematologic toxicity: Discontinue raltitrexed and manage with supportive measures (consider administering leucovorin).
Grade 3 hematologic toxicity (neutropenia or thrombocytopenia) or grade 2 GI toxicity (diarrhea or mucositis): Reduce dose by 25%.
Grade 4 hematologic toxicity (neutropenia or thrombocytopenia) or grade 3 GI toxicity (diarrhea or mucositis): Reduce dose by 50%.
Refer to adult dosing; use with caution.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Adverse reactions reported in adults.
>10%:
Dermatologic: Skin rash (14%)
Gastrointestinal: Abdominal pain (17% to 18%), anorexia (26% to 28%), constipation (13% to 15%), diarrhea (37% to 38%; grades 3/4: 11%), mucous membrane abnormality (12%), nausea (57% to 58%; grades 3/4: ≤12%), stomatitis (11%; grades 3/4: 2%), vomiting (37% to 38%; grades 3/4: ≤12%)
Hematologic & oncologic: Anemia (15% to 18%; grades 3/4: 7% to 8%), leukopenia (including neutropenia: 20% to 22%; grades 3/4: 12% to 13%)
Hepatic: Increased serum alanine aminotransferase (14% to 15%), increased serum aspartate aminotransferase (16% to 18%)
Nervous system: Asthenia (46% to 49%)
Miscellaneous: Fever (2% to 23%)
1% to 10%:
Cardiovascular: Cardiac abnormality (2%; including heart failure), cardiac arrhythmia (3%; including atrial fibrillation, sinus tachycardia, supraventricular tachycardia), peripheral edema (10%)
Dermatologic: Alopecia (6%), cellulitis (3%), diaphoresis (3% to 4%), pruritus (3%)
Endocrine & metabolic: Dehydration (6% to 7%), hypokalemia (2%), weight loss (6%)
Gastrointestinal: Dysgeusia (6%), dyspepsia (6%), flatulence (2% to 3%), xerostomia (2% to 3%)
Genitourinary: Urinary tract infection (3%)
Hematologic & oncologic: Thrombocytopenia (5% to 6%; grades 3/4: 4%)
Hepatic: Hyperbilirubinemia (2% to 3%), increased serum alkaline phosphatase (2% to 3%)
Infection: Infection (3%), sepsis (2% to 3%)
Nervous system: Chills (4%), depression (3%), dizziness (4% to 5%), headache (6%), hypertonia (<2%), insomnia (3% to 4%), malaise (4%), pain (4%), paresthesia (2% to 3%)
Neuromuscular & skeletal: Arthralgia (<2%), myalgia (3%)
Ophthalmic: Conjunctivitis (2% to 3%)
Renal: Increased serum creatinine (2% to 3%)
Respiratory: Dyspnea (4% to 5%), flu-like symptoms (6% to 8%), increased cough (5%), pharyngitis (4% to 5%)
Frequency not defined: Dermatologic: Desquamation
Postmarketing:
Gastrointestinal: Gastrointestinal hemorrhage
Hepatic: Acute hepatic failure (Raderer 2000), hepatotoxicity (including increased gamma-glutamyl transferase) (Massacesi 2003)
Respiratory: Interstitial pneumonitis (Schallier 2000)
Hypersensitivity to raltitrexed or any component of the formulation; severe renal and/or hepatic impairment; pregnancy or breastfeeding; use in patients who may become pregnant; use in children (<18 years of age).
Concerns related to adverse effects:
• Bone marrow suppression: Neutropenia, leukopenia, anemia, and thrombocytopenia may occur; neutropenia and thrombocytopenia may be severe. Bone marrow suppression is typically mild to moderate and generally occurs 7 to 14 days after treatment; recovery usually occurs by day 21. Use with caution in patients with preexisting bone marrow suppression.
• Gastrointestinal toxicity: Diarrhea, mucositis, and stomatitis may occur. Severe diarrhea with concomitant hematologic toxicity (neutropenia) may be life-threatening.
• Hepatotoxicity: Asymptomatic and self-limiting reversible ALT and AST elevations may occur.
• Malaise/weakness: May cause malaise/weakness; caution patients concerning operation of machinery/driving.
Special populations:
• Older adult: Use with caution in older adult patients. Monitor closely, especially for GI toxicity, such as diarrhea or mucositis.
• Radiation therapy recipients: Use with caution in patients who have received prior radiation therapy.
Not available in the US
Yes
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution Reconstituted, Intravenous:
Tomudex: 2 mg (1 ea)
IV: Administer as an infusion over 15 minutes.
When used in combination with cisplatin for malignant pleural mesothelioma (off-label use), administer raltitrexed first, followed by cisplatin (Ref).
This medication is not on the NIOSH (2024) list; however, it meets the criteria for a hazardous drug. Raltitrexed contains manufacturer's special handling information and is a cytotoxic drug (per product labeling).
Use appropriate precautions for receiving, handling, storage, preparation, dispensing, transporting, administration, and disposal. Follow NIOSH and USP 800 recommendations and institution-specific policies/procedures for appropriate containment strategy (NIOSH 2023; NIOSH 2024; USP-NF 2020).
Note: Not approved in the US.
Colorectal cancer, advanced: Treatment of advanced colorectal cancer.
Malignant pleural mesothelioma, advanced
Raltitrexed may be confused with methotrexate, PEMEtrexed, PRALAtrexate.
Tomudex may be confused with Temodal.
The Institute for Safe Medication Practices (ISMP) includes this medication among its list of drugs (chemotherapeutic agent; parenteral and oral; contraindicated in pregnancy) which have a heightened risk of causing significant patient harm when used in error (High-Alert Medications in Acute Care, Community/Ambulatory Care, and Long-Term Care Settings).
None known.
Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program by clicking on the “Launch drug interactions program” link above.
5-Aminosalicylic Acid Derivatives: May increase myelosuppressive effects of Myelosuppressive Agents. Risk C: Monitor
Abrocitinib: May increase immunosuppressive effects of Immunosuppressants (Cytotoxic Chemotherapy). Risk X: Avoid
Antithymocyte Globulin (Equine): Immunosuppressants (Cytotoxic Chemotherapy) may increase adverse/toxic effects of Antithymocyte Globulin (Equine). Specifically, these effects may be unmasked if the dose of cytotoxic chemotherapy is reduced. Immunosuppressants (Cytotoxic Chemotherapy) may increase immunosuppressive effects of Antithymocyte Globulin (Equine). Specifically, infections may occur with greater severity and/or atypical presentations. Risk C: Monitor
Antithyroid Agents: Myelosuppressive Agents may increase neutropenic effects of Antithyroid Agents. Risk C: Monitor
Baricitinib: Immunosuppressants (Cytotoxic Chemotherapy) may increase immunosuppressive effects of Baricitinib. Risk X: Avoid
BCG Products: Immunosuppressants (Cytotoxic Chemotherapy) may decrease therapeutic effects of BCG Products. Immunosuppressants (Cytotoxic Chemotherapy) may increase adverse/toxic effects of BCG Products. Specifically, the risk of vaccine-associated infection may be increased. Risk X: Avoid
Brincidofovir: Immunosuppressants (Cytotoxic Chemotherapy) may decrease therapeutic effects of Brincidofovir. Risk C: Monitor
Brivudine: May increase adverse/toxic effects of Immunosuppressants (Cytotoxic Chemotherapy). Risk X: Avoid
Chikungunya Vaccine (Live): Immunosuppressants (Cytotoxic Chemotherapy) may increase adverse/toxic effects of Chikungunya Vaccine (Live). Specifically, the risk of vaccine-associated infection may be increased. Immunosuppressants (Cytotoxic Chemotherapy) may decrease therapeutic effects of Chikungunya Vaccine (Live). Risk X: Avoid
Chloramphenicol (Ophthalmic): May increase adverse/toxic effects of Myelosuppressive Agents. Risk C: Monitor
Chloramphenicol (Systemic): Myelosuppressive Agents may increase myelosuppressive effects of Chloramphenicol (Systemic). Risk X: Avoid
Cladribine: Immunosuppressants (Cytotoxic Chemotherapy) may increase immunosuppressive effects of Cladribine. Risk X: Avoid
CloZAPine: Myelosuppressive Agents may increase adverse/toxic effects of CloZAPine. Specifically, the risk for neutropenia may be increased. Risk C: Monitor
Coccidioides immitis Skin Test: Coadministration of Immunosuppressants (Cytotoxic Chemotherapy) and Coccidioides immitis Skin Test may alter diagnostic results. Management: Consider discontinuing cytotoxic chemotherapy several weeks prior to coccidioides immitis skin antigen testing to increase the likelihood of accurate diagnostic results. Risk D: Consider Therapy Modification
COVID-19 Vaccine (Inactivated Virus): Immunosuppressants (Cytotoxic Chemotherapy) may decrease therapeutic effects of COVID-19 Vaccine (Inactivated Virus). Risk C: Monitor
COVID-19 Vaccine (mRNA): Immunosuppressants (Cytotoxic Chemotherapy) may decrease therapeutic effects of COVID-19 Vaccine (mRNA). Management: Give a 3-dose primary series for all patients aged 6 months and older taking immunosuppressive medications or therapies. Booster doses are recommended for certain age groups. See CDC guidance for details. Risk D: Consider Therapy Modification
COVID-19 Vaccine (Subunit): Immunosuppressants (Cytotoxic Chemotherapy) may decrease therapeutic effects of COVID-19 Vaccine (Subunit). Risk C: Monitor
Deferiprone: Myelosuppressive Agents may increase neutropenic effects of Deferiprone. Management: Avoid the concomitant use of deferiprone and myelosuppressive agents whenever possible. If this combination cannot be avoided, monitor the absolute neutrophil count more closely. Risk D: Consider Therapy Modification
Dengue Tetravalent Vaccine (Live): Immunosuppressants (Cytotoxic Chemotherapy) may decrease therapeutic effects of Dengue Tetravalent Vaccine (Live). Immunosuppressants (Cytotoxic Chemotherapy) may increase adverse/toxic effects of Dengue Tetravalent Vaccine (Live). Specifically, the risk of vaccine-associated infection may be increased. Risk X: Avoid
Denosumab: May increase immunosuppressive effects of Immunosuppressants (Cytotoxic Chemotherapy). Management: Consider the risk of serious infections versus the potential benefits of coadministration of denosumab and cytotoxic chemotherapy. If combined, monitor patients for signs/symptoms of serious infections. Risk D: Consider Therapy Modification
Deucravacitinib: May increase immunosuppressive effects of Immunosuppressants (Cytotoxic Chemotherapy). Risk X: Avoid
Etrasimod: May increase immunosuppressive effects of Immunosuppressants (Cytotoxic Chemotherapy). Risk X: Avoid
Fexinidazole: Myelosuppressive Agents may increase myelosuppressive effects of Fexinidazole. Risk X: Avoid
Filgotinib: May increase immunosuppressive effects of Immunosuppressants (Cytotoxic Chemotherapy). Risk X: Avoid
Folic Acid: May decrease therapeutic effects of Raltitrexed. Risk X: Avoid
Inebilizumab: Immunosuppressants (Cytotoxic Chemotherapy) may increase immunosuppressive effects of Inebilizumab. Risk C: Monitor
Influenza Virus Vaccines: Immunosuppressants (Cytotoxic Chemotherapy) may decrease therapeutic effects of Influenza Virus Vaccines. Management: Administer influenza vaccines at least 2 weeks prior to initiating chemotherapy if possible. If vaccination occurs less than 2 weeks prior to or during chemotherapy, revaccinate at least 3 months after therapy discontinued if immune competence restored. Risk D: Consider Therapy Modification
Leflunomide: Immunosuppressants (Cytotoxic Chemotherapy) may increase immunosuppressive effects of Leflunomide. Management: Increase the frequency of chronic monitoring of platelet, white blood cell count, and hemoglobin or hematocrit to monthly, instead of every 6 to 8 weeks, if leflunomide is coadministered with immunosuppressive agents, such as cytotoxic chemotherapy. Risk D: Consider Therapy Modification
Lenograstim: Antineoplastic Agents may decrease therapeutic effects of Lenograstim. Management: Avoid the use of lenograstim 24 hours before until 24 hours after the completion of myelosuppressive cytotoxic chemotherapy. Risk D: Consider Therapy Modification
Leucovorin Calcium-Levoleucovorin: May decrease therapeutic effects of Raltitrexed. Risk X: Avoid
Linezolid: May increase myelosuppressive effects of Myelosuppressive Agents. Risk C: Monitor
Lipegfilgrastim: Antineoplastic Agents may decrease therapeutic effects of Lipegfilgrastim. Management: Avoid concomitant use of lipegfilgrastim and myelosuppressive cytotoxic chemotherapy. Lipegfilgrastim should be administered at least 24 hours after the completion of myelosuppressive cytotoxic chemotherapy. Risk D: Consider Therapy Modification
Multivitamins/Minerals (with ADEK, Folate, Iron): May decrease therapeutic effects of Raltitrexed. Specifically, the folic acid contained in multivitamins is responsible for this potential interaction. Risk X: Avoid
Mumps- Rubella- or Varicella-Containing Live Vaccines: Immunosuppressants (Cytotoxic Chemotherapy) may decrease therapeutic effects of Mumps- Rubella- or Varicella-Containing Live Vaccines. Immunosuppressants (Cytotoxic Chemotherapy) may increase adverse/toxic effects of Mumps- Rubella- or Varicella-Containing Live Vaccines. Specifically, the risk of vaccine-associated infection may be increased. Risk X: Avoid
Nadofaragene Firadenovec: Immunosuppressants (Cytotoxic Chemotherapy) may increase adverse/toxic effects of Nadofaragene Firadenovec. Specifically, the risk of disseminated adenovirus infection may be increased. Risk X: Avoid
Natalizumab: Immunosuppressants (Cytotoxic Chemotherapy) may increase immunosuppressive effects of Natalizumab. Risk X: Avoid
Ocrelizumab: Immunosuppressants (Cytotoxic Chemotherapy) may increase immunosuppressive effects of Ocrelizumab. Risk C: Monitor
Ofatumumab: Immunosuppressants (Cytotoxic Chemotherapy) may increase immunosuppressive effects of Ofatumumab. Risk C: Monitor
Olaparib: Myelosuppressive Agents may increase myelosuppressive effects of Olaparib. Risk C: Monitor
Palifermin: May increase adverse/toxic effects of Antineoplastic Agents. Specifically, the duration and severity of oral mucositis may be increased. Management: Do not administer palifermin within 24 hours before, during infusion of, or within 24 hours after administration of myelotoxic chemotherapy. Risk D: Consider Therapy Modification
Pidotimod: Immunosuppressants (Cytotoxic Chemotherapy) may decrease therapeutic effects of Pidotimod. Risk C: Monitor
Pimecrolimus: May increase immunosuppressive effects of Immunosuppressants (Cytotoxic Chemotherapy). Risk X: Avoid
Piperacillin: May increase hypokalemic effects of Antineoplastic Agents. Risk C: Monitor
Pneumococcal Vaccines: Immunosuppressants (Cytotoxic Chemotherapy) may decrease therapeutic effects of Pneumococcal Vaccines. Risk C: Monitor
Poliovirus Vaccine (Live/Trivalent/Oral): Immunosuppressants (Cytotoxic Chemotherapy) may decrease therapeutic effects of Poliovirus Vaccine (Live/Trivalent/Oral). Immunosuppressants (Cytotoxic Chemotherapy) may increase adverse/toxic effects of Poliovirus Vaccine (Live/Trivalent/Oral). Specifically, the risk of vaccine-associated infection may be increased. Risk X: Avoid
Polymethylmethacrylate: Immunosuppressants (Cytotoxic Chemotherapy) may increase hypersensitivity effects of Polymethylmethacrylate. Management: Use caution when considering use of bovine collagen-containing implants such as the polymethylmethacrylate-based Bellafill brand implant in patients who are receiving immunosuppressants. Consider use of additional skin tests prior to administration. Risk D: Consider Therapy Modification
Promazine: May increase myelosuppressive effects of Myelosuppressive Agents. Risk C: Monitor
Pyrimethamine: May increase adverse/toxic effects of Raltitrexed. Risk C: Monitor
Rabies Vaccine: Immunosuppressants (Cytotoxic Chemotherapy) may decrease therapeutic effects of Rabies Vaccine. Management: Complete rabies vaccination at least 2 weeks before initiation of immunosuppressant therapy if possible. If combined, check for rabies antibody titers, and if vaccination is for post exposure prophylaxis, administer a 5th dose of the vaccine. Risk D: Consider Therapy Modification
Ritlecitinib: Immunosuppressants (Cytotoxic Chemotherapy) may increase immunosuppressive effects of Ritlecitinib. Risk X: Avoid
Ropeginterferon Alfa-2b: Myelosuppressive Agents may increase myelosuppressive effects of Ropeginterferon Alfa-2b. Management: Avoid coadministration of ropeginterferon alfa-2b and other myelosuppressive agents. If this combination cannot be avoided, monitor patients for excessive myelosuppressive effects. Risk D: Consider Therapy Modification
Ruxolitinib (Topical): Immunosuppressants (Cytotoxic Chemotherapy) may increase immunosuppressive effects of Ruxolitinib (Topical). Risk X: Avoid
Sipuleucel-T: Immunosuppressants (Cytotoxic Chemotherapy) may decrease therapeutic effects of Sipuleucel-T. Management: Consider reducing the dose or discontinuing the use of immunosuppressants, such as cytotoxic chemotherapy, prior to initiating sipuleucel-T therapy. Risk D: Consider Therapy Modification
Sphingosine 1-Phosphate (S1P) Receptor Modulators: May increase immunosuppressive effects of Immunosuppressants (Cytotoxic Chemotherapy). Risk C: Monitor
Tacrolimus (Topical): Immunosuppressants (Cytotoxic Chemotherapy) may increase immunosuppressive effects of Tacrolimus (Topical). Risk X: Avoid
Talimogene Laherparepvec: Immunosuppressants (Cytotoxic Chemotherapy) may increase adverse/toxic effects of Talimogene Laherparepvec. Specifically, the risk of infection from the live, attenuated herpes simplex virus contained in talimogene laherparepvec may be increased. Risk X: Avoid
Tertomotide: Immunosuppressants (Cytotoxic Chemotherapy) may decrease therapeutic effects of Tertomotide. Risk X: Avoid
Tofacitinib: Immunosuppressants (Cytotoxic Chemotherapy) may increase immunosuppressive effects of Tofacitinib. Risk X: Avoid
Typhoid Vaccine: Immunosuppressants (Cytotoxic Chemotherapy) may decrease therapeutic effects of Typhoid Vaccine. Immunosuppressants (Cytotoxic Chemotherapy) may increase adverse/toxic effects of Typhoid Vaccine. Specifically, the risk of vaccine-associated infection may be increased. Risk X: Avoid
Ublituximab: Immunosuppressants (Cytotoxic Chemotherapy) may increase immunosuppressive effects of Ublituximab. Risk C: Monitor
Upadacitinib: Immunosuppressants (Cytotoxic Chemotherapy) may increase immunosuppressive effects of Upadacitinib. Risk X: Avoid
Vaccines (Live): Immunosuppressants (Cytotoxic Chemotherapy) may increase adverse/toxic effects of Vaccines (Live). Specifically, the risk of vaccine-associated infection may be increased. Vaccines (Live) may decrease therapeutic effects of Immunosuppressants (Cytotoxic Chemotherapy). Risk X: Avoid
Vaccines (Non-Live/Inactivated/Non-Replicating): Immunosuppressants (Cytotoxic Chemotherapy) may decrease therapeutic effects of Vaccines (Non-Live/Inactivated/Non-Replicating). Management: Give non-live/inactivated/non-replicating vaccines at least 2 weeks prior to starting chemotherapy when possible. Patients vaccinated less than 14 days before or during chemotherapy should be revaccinated at least 3 months after therapy is complete. Risk D: Consider Therapy Modification
Yellow Fever Vaccine: Immunosuppressants (Cytotoxic Chemotherapy) may decrease therapeutic effects of Yellow Fever Vaccine. Immunosuppressants (Cytotoxic Chemotherapy) may increase adverse/toxic effects of Yellow Fever Vaccine. Specifically, the risk of vaccine-associated infection may be increased. Risk X: Avoid
Zoster Vaccine (Live/Attenuated): Immunosuppressants (Cytotoxic Chemotherapy) may increase adverse/toxic effects of Zoster Vaccine (Live/Attenuated). Specifically, the risk of vaccine-associated infection may be increased. Immunosuppressants (Cytotoxic Chemotherapy) may decrease therapeutic effects of Zoster Vaccine (Live/Attenuated). Risk X: Avoid
Use is contraindicated in patients who may become pregnant during treatment. Pregnancy should be excluded prior to treatment. Pregnancy should be avoided during treatment and for 6 months after the last raltitrexed dose if either partner is receiving treatment.
Use is contraindicated in patients who are pregnant.
Pregnant patients should not handle this medication.
Use in breastfeeding patients is contraindicated by the manufacturer.
Avoid folic acid, folinic acid (leucovorin calcium), and multivitamins with folic acid close to and during administration.
CBC with differential (at baseline, prior to each treatment, or weekly if GI toxicity observed); hepatic function tests and serum creatinine (at baseline and prior to each treatment). Monitor for signs of GI toxicity. Evaluate pregnancy status prior to use in patients who may become pregnant.
The American Society of Clinical Oncology hepatitis B virus (HBV) screening and management provisional clinical opinion (ASCO [Hwang 2020]) recommends HBV screening with hepatitis B surface antigen, hepatitis B core antibody, total Ig or IgG, and antibody to hepatitis B surface antigen prior to beginning (or at the beginning of) systemic anticancer therapy; do not delay treatment for screening/results. Detection of chronic or past HBV infection requires a risk assessment to determine antiviral prophylaxis requirements, monitoring, and follow-up.
Raltitrexed is a folate analogue that selectively inhibits thymidylate synthase, blocking purine synthesis. This results in an overall inhibition of DNA synthesis.
Distribution: Vss: 548 L
Protein binding: 93%
Metabolism: Undergoes extensive intracellular metabolism to active polyglutamate forms; appears to be little or no systemic metabolism of the drug
Half-life elimination: Triphasic; Beta: ~2 hours; Terminal: 198 hours
Excretion: Urine (~50% as unchanged drug); feces (~15%)
Altered kidney function: Plasma clearance is reduced approximately 50% in patients with CrCl 25 to 65 mL/minute.
Hepatic function impairment: Mild to moderate impairment results in a reduction in plasma clearance of less than 25%.
