Version May 2024
Dermatologic conditions: Topical: Apply a minimum of twice daily or as often as necessary
Refer to adult dosing.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Frequency not defined.
Central nervous system: Transient stinging of the skin (at application site)
There are no contraindications listed in the manufacturer's labeling.
Disease-related concerns:
• Hemoglobin deficiency: Wound healing may be retarded in the presence of hemoglobin deficiency.
• Zinc deficiency: Wound healing may be retarded in the presence of zinc deficiency.
Dosage form specific issues:
• Aerosol: Flammable; do not expose to high temperatures or flame.
Other warnings/precautions:
• Appropriate use: For external use only; avoid contact with eyes. Do not apply to fresh arterial clots.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Aerosol, spray, topical:
TBC: Trypsin 0.1 mg, balsam Peru 72.5 mg, and castor oil 650 mg per 0.82 mL (60 g [DSC], 120 g [DSC])
No
Gel (Optase External)
0.12-788-87 mg/g (6 g): $8.75
Disclaimer: The pricing data provide a representative AWP and/or AAWP price from a single manufacturer of the brand and/or generic product, respectively. The pricing data should be used for benchmarking purposes only, and as such should not be used to set or adjudicate any prices for reimbursement or purchasing functions. Pricing data is updated monthly.
Do not apply on fresh arterial clots.
Aerosol spray: Shake can well before spraying; hold can upright ~12” from area to be treated, and spray and coat wound rapidly (temporary stinging may occur). May be used with appropriate wet dressing if needed or wound may be left unbandaged. To remove, wash gently with water.
Ointment: Apply a thin film over the area being treated. May be used with appropriate dressing if needed or wound may be left unbandaged. To remove, wash gently with appropriate wound cleanser.
Granulex: Treatment of decubitus ulcers, varicose ulcers, debridement of eschar, dehiscent wounds and sunburn; promote wound healing; reduce odor from necrotic wounds
Vasolex: Treatment of decubitus ulcers, varicose ulcers, and dehiscent wounds; promote wound healing; reduce odor from necrotic wounds
Granulex [PR] may be confused with Regranex brand name for becaplermin [US and multiple international markets]
None known.
Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the Lexicomp drug interactions program by clicking on the “Launch drug interactions program” link above.
Polyethylene Glycol-Electrolyte Solution: Laxatives (Stimulant) may enhance the adverse/toxic effect of Polyethylene Glycol-Electrolyte Solution. Specifically, the risk of colonic mucosal aphthous ulcerations may be increased. Management: Consider avoiding this combination due to a potential for increased risk of colonic mucosal aphthous ulcerations. Risk D: Consider therapy modification
Sodium Sulfate: Laxatives (Stimulant) may enhance the adverse/toxic effect of Sodium Sulfate. Specifically, the risk of mucosal ulceration or ischemic colitis may be increased. Risk X: Avoid combination
Trypsin may be used to debride necrotic tissue; balsam peru stimulates circulation at the wound site and may be mildly bactericidal; castor oil improves epithelialization, acts as a protectant covering and helps reduce pain
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