Comparison of proposed risk assessment models to predict malignancy in solitary fibrous tumor (SFT) of the pleura

	England DM, et al 1989	De Perrot M, et al 2002	Tapias LC, et al 2013	Diebold M, et al 2017
Histologic risk factors for malignancy
Mitotic figures per 10 HPF	>4	>4	≥4	≥4
Hypercellularity	+	+	+
Pleomorphism	+	+
Necrosis	+	+	+	+
Hemorrhage	+		+
Stromal/vascular invasion		+
Anatomic high risk factors
Size	>10 cm		≥10 cm	≥10 cm
Pedunculation	Sessile	Sessile	Sessile
Site	Parietal pleura	Not included	Parietal pleura
Biomarker risk factors
MIB-1 proliferation index				≥10%
Number of criteria needed for high risk ("malignant") diagnosis
	1 or more histologic criteria	1 or more histologic criteria	Any 3 histologic and anatomic risk factors	2 or more histologic, anatomic, or biomarker risk factors

HPF: high-power field.

References:

England DM, Hochholzer L, McCarthy MJ. Localized benign and malignant fibrous tumors of the pleura. A clinicopathologic review of 223 cases. Am J Surg Pathol 1989; 13:640.
de Perrot M, Fischer S, Bründler MA, et al. Solitary fibrous tumors of the pleura. Ann Thorac Surg 2002; 74:285.
Tapias LF, Mino-Kenudson M, Lee H, et al. Risk factor analysis for the recurrence of resected solitary fibrous tumours of the pleura: a 33-year experience and proposal for a scoring system. Eur J Cardiothorac Surg 2013; 44:111.
Diebold M, Soltermann A, Hottinger S, et al. Prognostic value of MIB-1 proliferation index in solitary fibrous tumors of the pleura implemented in a new score - a multicenter study. Respir Res 2017; 18:210.

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