Light microscopy changes in kidney biopsy specimens from patients with Mesoamerican nephropathy

Light microscopy changes in kidney biopsy specimens from patients with Mesoamerican nephropathy.
(A) Glomerular enlargement was seen in all biopsy specimens (hematoxylin and eosin). In two patients, focal segmental lesions were found in glomeruli.
(B) In one patient, the lesion was of cellular type (periodic acid-Schiff).
(C) Mild to moderate tubular atrophy and chronic interstitial inflammation were seen in most patients (Ladewig).
(D) Most arteries showed no intimal fibrosis (hematoxylin and eosin); three of eight patients displayed mild arteriolar hyalinosis.