Dose | Category | |
Acid suppression (IV)* | ||
Esomeprazole | Intermittent dosing: | PPI |
Infants: 0.5 to 1 mg/kg/dose IV once daily | ||
Children 1 to 17 years: | ||
<55 kg: 10 mg IV once or twice daily | ||
≥55 kg: 20 mg IV once or twice daily | ||
Adults: 40 mg IV twice daily | ||
Continuous IV infusion:[1] | ||
1 mg/kg IV bolus (maximum 80 mg), followed by infusion of 0.1 mg/kg/hour (maximum 8 mg/hour)¶ | ||
Omeprazole (IV preparation not available in the United States) | Children and adolescents:[2] 0.5 to 3 mg/kg IV daily in 1 or 2 divided doses (maximum 80 mg daily) | PPI |
Adults: 40 mg IV twice daily | ||
Pantoprazole | Intermittent dosing: | PPI |
Children and adolescents: | ||
<40 kg: 0.5 to 1 mg/kg IV once or twice daily | ||
>40 kg: 20 to 40 mg IV once or twice daily | ||
Adults: 40 mg IV twice daily | ||
Continuous IV infusion:[1] | ||
1 mg/kg IV bolus (maximum 80 mg), followed by an infusion of 0.1 mg/kg/hour (maximum 8 mg/hour)¶ | ||
Acid suppression (oral)Δ | ||
Omeprazole | Children and adolescents: 1 to 3 mg/kg daily[3] (maximum 80 mg daily) in 1 or 2 divided doses | PPI |
Adults: 40 mg twice daily initially, followed by 20 to 40 mg once daily (maintenance dose, once risk of recurrent bleeding is low) | ||
Esomeprazole | Infants 1 month to 1 year (daily): | PPI |
3 to 5 kg: 2.5 mg | ||
5 to 7.5 kg: 5 mg | ||
7.5 to 12 kg: 10 mg | ||
Children 1 to 11 years (daily): | ||
Weight <20 kg: 10 mg | ||
Weight ≥20 kg: 10 mg or 20 mg◊ | ||
Children ≥12 years and adults: 40 mg twice daily initially, followed by 20 to 40 mg once daily (as a maintenance dose, once risk of recurrent bleeding is low) | ||
Pantoprazole | Children 5 to 11 years: | PPI |
Weight 15 to 40 kg: 20 mg once daily | ||
Weight >40 kg: Use adult dose | ||
Children ≥12 years and adults: 40 mg twice daily initially, followed by 20 to 40 mg once daily (as a maintenance dose, once risk of recurrent bleeding is low) | ||
Vasoactive agents | ||
Octreotide | Children: 1 to 2 microgram/kg IV bolus (maximum 50 micrograms), followed by 1 to 2 microgram/kg/hour as a continuous IV infusion (maximum 50 micrograms per hour)[4]; initial bolus may be repeated once in the first hour if needed | Somatostatin analog |
Adults: 50 microgram IV bolus followed by a continuous IV infusion of 50 micrograms per hour; initial bolus may be repeated once in first hour if needed |
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