Version May 2024
Cerebral blood flow: Inhalation (based on 70 kg patient): 10 to 30 mCi (370 to 1,110 MBq).
Pulmonary function, including imaging: Inhalation (based on 70 kg patient): 2 to 30 mCi (74 to 1,110 MBq).
There are no dosage adjustments provided in the manufacturer’s labeling.
There are no dosage adjustments provided in the manufacturer’s labeling.
Refer to adult dosing.
There are no adverse reactions listed in the manufacturer’s labeling.
There are no contraindications listed in the manufacturer’s labeling.
Special handling:
• Radiopharmaceutical: Use appropriate precautions for handling, disposal, and minimizing exposure to patients and health care personnel. Use only under supervision of individuals with experience/training in the handling of radioactive materials approved by the applicable regulatory authority.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Gas, Inhalation:
Generic: 20 mCi (1 ea)
Gas, Inhalation [preservative free]:
Generic: 370 MBq (1 ea)
Yes
Gas (Xenon Xe 133 Inhalation)
10MCI (per each): $291.54 - $391.88
20MCI (per each): $593.73 - $635.45
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
Administered by inhalation from closed respirator systems or spirometers; ensure delivery system is leak proof. Do not allow xenon Xe 133 to stand in tubing or respirator containers. Measure dose with a suitable radioactivity calibration system immediately prior to administration. Radiopharmaceutical; use appropriate precautions for handling and disposal. Use waterproof gloves and effective radiation shielding when handling.
Diagnostic imaging: Radioactive diagnostic agent indicated for lung imaging, pulmonary function evaluation, and cerebral flow assessment.
Radiopharmaceutical: Use appropriate precaution for handling, disposal, and minimizing exposure to patients and health care personnel. Use under supervision of experienced personnel. Should be stored in original lead container or adequate radiation shield.
None known.
There are no known significant interactions.
Pregnancy status should be evaluated prior to use in women of reproductive potential (SNM 2010).
Exposure to the fetus following maternal inhalation of xenon Xe 133 gas is limited (Huda 2005; Jacoby 1972). When lung scintigraphy is required in a pregnant woman, the procedure should be modified to decrease fetal risk (SNM [Parker 2012]). Elective diagnostic procedures should be delayed until after delivery (SNM 2010).
It is not known if xenon Xe-133 gas is present in breast milk.
The manufacturer recommends caution be used if administered to a breastfeeding woman. When lung scintigraphy is required in a lactating woman, breastfeeding does not need to be interrupted due to xenon Xe 133 gas (SNM [Parker 2012]). Elective diagnostic procedures should be delayed until breastfeeding has stopped (SNM 2010).
Radioactive diagnostic gas that passes through cell membranes and freely exchanges between blood and tissue. Enter the alveolar wall and the pulmonary venous circulation via the capillaries. Most of the xenon Xe 133 that enters the circulation from a single breath is returned to the lungs and exhaled after a single pass through the peripheral circulation. In concentrations used for diagnostic purposes it is physiologically inactive.
Distribution: Body fat, blood, plasma, and water or protein solutions (physiologically inactive)
Half-life elimination: 5.3 days
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