Initial daily dose | Minimum interval to assess effect before increasing dose | Usual effective daily dose range* | Metabolism and clearance | |
Gabapentinoids (alpha-2-delta calcium channel ligands) | ||||
Gabapentin (IR) | 100 to 300 mg 2 hours before bedtime | 5 to 7 days | 900 to 2400 mg as a single dose or in two divided doses (eg, one-third an hour before symptoms start and two-thirds before bed) |
|
Gabapentin enacarbil (ER) | 300 to 600 mg in early evening (eg, ~5 PM) | 5 to 7 days | 600 mgΔ |
|
Pregabalin (IR) | 50 to 75 mg 1 to 3 hours before bedtime | 5 to 7 days | 150 to 450 mg |
|
Dopamine agonists | ||||
Pramipexole (IR) | 0.125 mg 2 to 3 hours before bedtime | 2 to 3 days | 0.25 to 0.50 mg |
|
Ropinirole (IR) | 0.25 mg 1 to 3 hours before bedtime | 2 to 3 days | 2 to 4 mg |
|
Rotigotine transdermal patch | 1 mg per 24 hour patch | 5 to 7 days | 2 to 3 mg per 24 hour patch |
|
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