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Racemic epinephrine and aluminum potassium sulfate: Drug information

Racemic epinephrine and aluminum potassium sulfate: Drug information
For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: US
  • GingiBRAID +
Pharmacologic Category
  • Adrenergic Agonist Agent;
  • Alpha-/Beta- Agonist;
  • Astringent;
  • Vasoconstrictor
Dosing: Adult
Dental aid

Dental aid: Pass the impregnated cord around the neck of the tooth and place into gingival sulcus; leave cord in sulcus for up to 5 minutes; normal tissue moisture, water, or gingival retraction solutions activate impregnated cord. Limit use to one quadrant of the mouth at a time.

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in the manufacturer’s labeling.

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer’s labeling.

Dosing: Older Adult

Refer to adult dosing; use with caution.

Adverse Reactions

No data reported.

Contraindications

Hypersensitivity to epinephrine, sulfites, aluminum-containing products, or any component of the formulation; cardiovascular disease, hypertension, hyperthyroidism, diabetes, or congestive glaucoma; concurrent antidepressant use; do not apply to areas of heavy or deep bleeding or overexposed bone

Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.

Warnings/Precautions

Other warnings/precautions:

• Appropriate use: Caution should be exercised whenever using gingival retraction cords with epinephrine since it delivers vasoconstrictor doses of racemic epinephrine to patients; the general medical history should be thoroughly evaluated before using in any patient.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Retraction cord, for gingival sulcus placement:

GingiBRAID +:

0e fine: Epinephrine 0.10 – 0.30 mg and aluminum potassium sulfate 0.05 – 0.25 mg per inch

1e small: Epinephrine 0.20 – 0.60 mg and aluminum potassium sulfate 0.15 – 0.35 mg per inch

2e medium: Epinephrine 0.40 – 0.80 mg and aluminum potassium sulfate 0.20 – 0.50 mg per inch

3e large: Epinephrine 0.60 – 1.20 mg and aluminum potassium sulfate 0.30 – 0.80 mg per inch

Generic Equivalent Available: US

No

Use: Labeled Indications

Dental aid: Aids in temporary gingival retraction and hemostasis procedures

Metabolism/Transport Effects

None known.

Drug Interactions

Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the Lexicomp drug interactions program by clicking on the “Launch drug interactions program” link above.

Beta-Blockers (Beta1 Selective): May diminish the therapeutic effect of Epinephrine (Racemic). Risk C: Monitor therapy

Beta-Blockers (Nonselective): May enhance the hypertensive effect of Epinephrine (Racemic). Risk C: Monitor therapy

Beta-Blockers (with Alpha-Blocking Properties): May diminish the therapeutic effect of Epinephrine (Racemic). Risk C: Monitor therapy

Monoamine Oxidase Inhibitors: May enhance the hypertensive effect of Epinephrine (Racemic). Risk C: Monitor therapy

Mechanism of Action

Epinephrine stimulates alpha1 adrenergic receptors to cause vasoconstriction in blood vessels in gingiva; aluminum potassium sulfate, precipitates tissue and blood proteins

Pharmacokinetics (Adult Data Unless Noted)

No data reported.

  1. GingiBraid+, GingiBraid+ Shortcut, UniBraid+, GingiCord (epinephrine [racemic] and aluminum potassium sulfate) [prescribing information]. Orange, CA: Kerr Corporation; received January 2018.
Topic 10137 Version 67.0

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