Version July 2025
INTRODUCTION —
Infection prevention and control (hereafter "infection prevention") is grounded in quality improvement activities and is critical for patient safety [1,2]. Infection prevention programs use protocols and interventions to decrease the risk of health care-associated infection (HAI). HAIs are the most common complication seen in hospitalized patients and increase morbidity, mortality, costs, and length of stay, even after adjustment for underlying illness [3].
This topic will review the general principles of infection control. Isolation precautions for preventing transmission of infection and issues related to infection control for coronavirus disease 2019 (COVID-19) are reviewed separately. (See "Infection prevention: Precautions for preventing transmission of infection" and "COVID-19: Infection prevention for persons with SARS-CoV-2 infection".)
INFECTION PREVENTION PROGRAMS
Background — The field of infection prevention emerged from the results of the Study of the Efficacy of Nosocomial Infection Control (SENIC) [4]. The SENIC study demonstrated that four components were essential to an effective infection prevention and control program. These included (i) surveillance with feedback of infection rates to hospital staff, (ii) enforcement of preventive practices, (iii) a supervising infection preventionist (IP) to collect and analyze surveillance data, and (iv) the involvement of a clinician or microbiologist with specialized training in infection prevention and control. Programs with these elements reduced rates of the four most common health care-associated infections (HAIs) by 32 percent [4,5]. Subsequently, regulatory mandates led to the establishment of formal infection prevention programs, typically supervised by clinicians and/or trained nurses and overseen by hospital committees. Increasing hospital regulations, scrutiny from accreditation groups, public reporting of infection-related outcomes, and impact on hospital reimbursement have solidified infection prevention programs as a key component of health care in all settings.
The terminology surrounding infection prevention in health care has evolved over time. Initially, infection control teams sought to monitor "nosocomial" infections (ie, infections acquired in the hospital). More recently, the focus has shifted from monitoring to preventing HAIs. Similarly, as health care delivery has shifted from the hospital to various inpatient and outpatient venues, the term "health care epidemiology" has emerged to encompass infection prevention activities in the multiple areas where health care is delivered [3]. Additionally, the focus for infection prevention programs has evolved and expanded due to rising rates of antimicrobial resistance, aging populations, and increased use of immunosuppressive therapies.
Resourcing — The recommendation of one full-time equivalent (FTE) IP per 250 beds (0.4 IPs per 100 beds) was initially highlighted in the aforementioned SENIC study in 1985 [6]. However, the scope and role of infection prevention has changed significantly since that time. A Delphi project in 2002 recommended IP staffing to be a minimum of one FTE, regardless of size or setting, and the authors recommended that FTEs be increased with the size of the hospital [7].
Median infection control nurse staffing was estimated to be one IP per 167 beds in a United States hospital survey published in 2009 [8], while in Australia it was estimated to be one FTE per 152 beds [9].
In Canada, they estimated the infection prevention and control needs as three FTE IPs per 500 beds in acute care hospitals and one FTE IP per 150 to 250 beds in long-term care facilities. They highlighted program demands being related to restructuring in acute care and other health care sectors, with increasingly seriously ill and immunocompromised patients, growing surveillance demands, and expanding antimicrobial resistance [10]. In many settings, infection prevention personnel have multiple nonprevention responsibilities, including employee health and quality management [11].
A review of the crucial elements for the organization of effective infection prevention programs in hospitals and key components for implementation of monitoring identified the following key components:
●Organization of infection control at the hospital level
●Ward occupancy, staffing, and workload
●Employment of pool or agency nurses kept to a minimum
●Availability of and ease of access to materials, equipment, and optimum ergonomics
●Appropriate use of guidelines
●Education and training
●Standardized auditing
●Surveillance and feedback
●Multimodal and multidisciplinary prevention programs that include behavioural change
●Engagement of strategy champions
●Positive organizational culture
Goals — In general, infection prevention programs focus on two broad goals to increase patient safety: reducing the risk of acquisition or transmission of infection following exposure to health care settings (particularly from multidrug-resistant organisms) and reducing the risk of device- and procedure-related infections. In addition, these programs are increasingly charged with protecting health care personnel, visitors, and others and meeting accreditation and regulatory standards [12].
GENERAL PRINCIPLES —
The scope of a health care institution's infection prevention and control/health care epidemiology program should be driven by the size and complexity of the institution's patient population; the population's risk for health care-associated infection (HAI); and local, state, and national regulatory and accreditation requirements [13]. In most hospitals, members of the infection prevention team participate in regulatory, patient safety, and quality improvement initiatives.
Responsibilities — The typical infection prevention team has numerous oversight functions and responsibilities:
●Surveillance and feedback – Monitoring rates of HAIs includes surveillance for the following infections:
•Device and procedure-related infections
•Infections caused by multidrug-resistant organisms
•Epidemiologically important infections (eg, Staphylococcus aureus bacteremia, Clostridioides [formerly Clostridium] difficile infection)
●Hospital outbreak investigation – Infection prevention teams need to be familiar with the likely sources of outbreaks of infection in hospitals, how they are affected by hospital design and construction, and how they may best be investigated and remediated [14]. Outbreak sources in hospitals commonly consist of inanimate surface and device contamination, health care workers, other patients, and hospital water sources.
For example, waterborne outbreaks have occurred in health care settings with new reservoirs, including electronic faucets (Pseudomonas aeruginosa and Legionella spp), decorative water wall fountains (Legionella spp), and heater-cooler devices used in cardiac surgery (Mycobacterium chimaera) [15,16].
Hospital sinks, drains, showers, wash basins, and tap water have been the reservoir of infections caused by nontuberculous mycobacterial species, fungi, and multidrug-resistant gram-negative pathogens [15,16]. Molecular typing has been increasingly applied to hospital outbreak investigation, including the use of pulsed-field gel electrophoresis followed by random amplification of polymorphic deoxyribonucleic acid (DNA) and whole-genome and shotgun metagenomic sequencing [15,17,18].
●Education of health care providers and patients.
●Performance improvement to prevent or reduce HAIs.
●Reporting of HAIs.
●Occupational infection prevention for health care providers.
The programs are often led by a health care epidemiologist, who must have formal support from hospital administration [19].
The Society for Healthcare Epidemiology of America recommends the following core competencies for a successful health care epidemiologist [20]:
●Training in:
•Clinical infectious disease/pathogen transmission
•Microbiologic and laboratory diagnostic techniques
•Knowledge of quality improvement science
•Public health and emergency preparedness
●Skills in:
•Leadership
•Data management
•Program implementation, assessment, and advocacy
•Outcomes assessment
Monitoring infection prevention programs — The infection prevention team develops, implements, and monitors the success of the following infection prevention protocols and interventions to achieve the goals of the program and of the hospital:
●Surveillance data analysis and feedback.
●Hand hygiene compliance rates.
●Health care provider education completion.
●Cleaning/disinfecting medical equipment.
●Cleaning/disinfecting the health care environment.
●Environmental infection control (including air handling, water supply, and construction-related issues).
●Isolation precautions and the use of personal protective equipment (PPE). Educating staff on the use of appropriate PPE is an integral part of infection prevention within hospitals. (See "Infection prevention: Precautions for preventing transmission of infection".)
These interventions may be described as "horizontal", in which an intervention may prevent infection from many organisms (eg, surveillance, hand hygiene, and cleaning/disinfection), or "vertical", in which an intervention may prevent infection from a specific organism (eg, isolation precautions) [21].
General principles related to surveillance and feedback, regulations that impact infection prevention programs, and environmental cleaning/disinfection will be discussed below. Issues related to use of surveillance for control of specific pathogens such as methicillin-resistant S. aureus (MRSA) and vancomycin-resistant enterococci (VRE) are discussed separately. (See "Methicillin-resistant Staphylococcus aureus (MRSA) in adults: Prevention and control", section on 'Role of active surveillance' and "Vancomycin-resistant enterococci: Epidemiology, prevention, and control", section on 'Surveillance cultures'.)
SURVEILLANCE AND FEEDBACK —
Surveillance for health care-associated infections (HAIs) is an essential component of infection prevention [6]. Effective surveillance involves counting cases and calculating rates of infections [22-24]. Surveillance data are useful for identifying necessary interventions and also for assessing the efficacy of interventions to improve infection rates [25-27]. Surveillance data should be reported to hospital leadership, personnel involved in patient care, and to monitoring agencies such as state health departments or statewide or national surveillance programs according to local requirements [6,28-31].
In the United States, most programs perform surveillance using standardized definitions and methods developed by the Centers for Disease Control and Prevention (CDC)'s National Healthcare Safety Network (NHSN) [32-34]. In Europe, some countries use the NHSN's definitions, while others use European definitions from the European Centre for Disease Prevention and Control (ECDC) and Hospitals in Europe Link for Infection Control through surveillance (HELICS/IPSE) project. In general, there is excellent concordance between United States and European definitions of pneumonia and primary bloodstream infection, and rates of infection between countries can be compared at least for some HAIs [35,36].
Surveillance data may be used for both intrahospital comparison (ie, comparing the rate of infection in a particular hospital with a benchmark for similar hospitals) as well as interhospital comparison (ie, comparing infection rates between hospitals). In addition, comparing surveillance data between hospitals is subject to bias; risk adjustment for clinical factors is required but may not be sufficient [37-44]. (See 'Regulatory requirements and public reporting' below.)
Risk assessment is the cornerstone of designing an organization-specific surveillance program and involves identifying the most important populations and infections to follow so that resources can be focused on the most worthwhile prevention activities [13]. Many hospitals perform surveillance for the following infections:
●Surgical site infections
●Catheter-associated urinary tract infections
●Central line-associated bloodstream infections
●Pneumonia, particularly ventilator-associated pneumonia
●C. difficile infections
●Infections caused by multidrug-resistant organisms, including carbapenem-resistant Enterobacterales
Surveillance for all types of infection may not be possible in all settings; at a minimum, surveillance should be targeted to the following categories:
●Patients or care units at high risk for infection (for example, patients in intensive care units)
●Particular infections that are highly preventable and/or associated with substantial morbidity
●Emerging infections
Components of surveillance — Components of effective surveillance include the following [45,46]:
●Standardized definitions
●Routine review of microbiologic and clinical records
●Review of discharge diagnoses
●Review of records of patients who are readmitted after surgical procedures or patients who undergo reoperation
●Review of autopsy, radiologic, and pathologic reports
●Review of known or suspected infections among clinical personnel
Data collection and automation — Traditional manual surveillance methods are labor intensive, lack standardization, and are limited by inter-observer variability [47,48]. Electronic surveillance systems are becoming integral to routine infection control activities and have the potential to improve infection control outcomes in surveillance, prevention, and connections with public health [49].
Semi-automated and fully automated electronic surveillance systems are now widely used:
●Semi-automated electronic surveillance systems are used by many infection prevention programs. These systems filter data from laboratory, pharmacy, and admission/discharge/transfer records and have been found to successfully perform surveillance for various types of HAIs, including surgical site infections and central line-associated bloodsteam infections [50]. Such systems also have the potential to identify outbreaks that may be missed by routine detection methods [51]. They do, however, require substantial user input, have limitations with regard to interfacility comparison, and do not replace the need for chart review [46,48,51].
●Fully automated electronic surveillance systems function autonomously via a complex series of algorithms to identify HAIs; such systems generally do not require user input or chart review but may still include some manual steps [52-54]. The systems mine the electronic health record to collect data on clinical signs and symptoms, medical procedure details (eg, duration of surgery), and medical device exposure data (eg, duration of catheterization) [52]. Some systems require adjustment of algorithms for specific populations (such as those in an intensive care unit) [55]. Digital phenotypes hold promise in automating surveillance of HAIs by detecting information about individual patients (eg, fever, prescriptions, diagnoses, laboratory reports) that may indicate the presence of an HAI [56,57].
Implementation of automated surveillance systems in practice is complicated by practical challenges regarding the availability of high-quality data, electronic health record standardization, specialized information technology and infection control personnel, and costs [48]. As hospitals adopt medical record systems that meet uniform standards and regulatory requirements, the costs associated with building interfaces to collect and analyze clinical data, and the ability to compare rates between facilities and regions, are likely to improve [48,52]. Machine learning and artificial intelligence algorithms may eventually streamline surveillance practices, but these tools are not yet widely available nor validated [58].
Validation of surveillance data is necessary to ensure scientific credibility and identify methodologic problems [59]. Automated surveillance data should also undergo clinical and technical validation in all contexts, including validation of the source data, algorithms, denominator data, and an assessment of the ability to provide reliable benchmark data [48]. The results of validation studies are important for informing interventions to improve surveillance data quality, especially if validation studies reveal that the quality of surveillance data is suboptimal [60,61].
Point prevalence surveys — No single surveillance system can provide estimates of the burden of all types of HAIs across acute care patient populations. Point prevalence surveys (PPS) provide an alternative to continuous and targeted surveillance. Data regarding infections are captured at a single point in time, and surveys are generally easy to conduct, relatively inexpensive, and not time consuming. Moreover, the ability to evaluate a broader scope of infections and include increased numbers of health services within a shorter period of time, plus the possibility of more rapid data analysis and feedback, are recognised benefits of performing these surveys [62].
Starting in 2009, the CDC developed and conducted a multistate PPS across 183 hospitals [63]. Prevalence surveys had already been used in other countries to describe the scope and magnitude of the problem of HAIs and were shown to be useful in monitoring the effectiveness of infection control programs [64]. While a one-off PPS does highlight key issues, serial surveys provide even more comprehensive data and trends over time [62].
The CDC's PPS found that device-associated infections, which had been a major focus of infection prevention, accounted for only one-quarter of HAIs. Infections not associated with either devices or operative procedures (including C. difficile infections, other gastrointestinal infections, and nonventilator-associated pneumonia) accounted for approximately half of all HAIs [63]. The authors identified that the national estimates generated by the PPS for selected types of HAI were remarkably similar to estimates from other data sources, specifically NHSN data. They recommended that trends in the epidemiology of HAIs and the success of prevention measures may be achieved through repeated PPS, utilising consistent methodology.
PPS are typically undertaken on medical, surgical, and specialty acute care wards that admit patients for overnight stays and can allow HAIs to be reported by site, type of patient, specialty, presence of in situ indwelling medical devices, microbiology, antimicrobial use, and geographical location. It is recommended that PPS be repeated every three to five years.
The ECDC's methodology [65] has been widely utilised and validated for national HAI PPS throughout Europe [66,67], Australia [68], Africa [69], and Latin America [70]; it is similar to that used by the CDC [63]. Validation of PPS data is also important and may be based on the ECDC validation model [71].
EDUCATION AND TRAINING OF HEALTH CARE WORKERS —
Education and training of health care personnel are critical functions to prevent health care-associated infections (HAIs) and core functions of infection prevention and control programs. Focused training for various disciplines has been effective in durably reducing HAIs [72]. Routine in-service training should be directed toward health care personnel of all disciplines, including clinicians, nurses, medical and nursing students, as well as other staff with direct or indirect contact with patients or equipment. Training should be tailored to the appropriate educational level, learning styles, and work duties of the employees [13]. The training should incorporate hand hygiene and all tasks for which personnel are responsible and incorporate assessment of well-defined competencies for each task [73].
Basic infection prevention education and training should include numerous topics including but not limited to:
●Hand hygiene
●Aseptic technique
●Injection safety practices
●Equipment reprocessing
●Single-use devices
●Single- and multi-dose medication vials
●Personal protective equipment
●Standard- and transmission-based precautions
●Cleaning and disinfection
REGULATORY REQUIREMENTS AND PUBLIC REPORTING —
Regulatory burden has increased significantly for infection prevention programs over the past decade. Governments may directly regulate patient safety with mandatory reporting legislation. Alternatively, governments may require health care facilities to report to professional regulatory bodies or to create and enforce their own policies [74].
●Regulatory entities in the United States – The main regulatory organizations for infection prevention programs in the United States include federal agencies and accreditation organizations. Additional regulations and reporting requirements vary by state. The provides information on infection prevention-related regulations [75].
The National Quality Forum (NQF) endorses 25 measures related to patient safety, several of which are related to infection prevention [76]. Measures endorsed by NQF often translate into reporting requirements for hospitals, which they are required to report as a condition of participation in Centers for Medicare and Medicaid Services (CMS). Hospitals that perform well on these measures receive additional incentive payments. Data are posted for public reporting allowing the public to compare various quality metrics, including patient experiences, process measures, and infection data [77].
The Occupational Safety and Health Administration (OSHA) provides standards and directives to improve infection prevention for health care providers [78]. In general, these focus on prevention of infections from bloodborne pathogens following exposure to blood or body fluids and personal protective equipment for health care providers.
The Joint Commission places particular emphasis on infection prevention when providing accreditation to health care organizations [79]. Infection prevention programs in acute care hospitals must develop policies and procedures to meet specific goals related to:
•Infection prevention team staffing and institutional support
•Hand hygiene policies and practices
•Prevention of infections caused by multidrug-resistant organisms, including regular assessment (via surveillance) and education for health care providers
•Prevention of central line-associated bloodstream infection
•Prevention of surgical site infections
•Prevention of catheter-associated urinary tract infections
●Regulatory entities outside the United States – Similar regulatory agencies oversee infection prevention regulations throughout the world. For example, the European Commission and other agencies, in particular the European Academies Science Advisory Council and the European Centre for Disease Prevention and Control (ECDC), play a role in integrated surveillance in Europe [80]. The ECDC established HAI-Net, a network of national and regional networks collecting surveillance data across Europe [81].
In Canada, mandatory reporting of health care-associated infections (HAIs) is a provincial, not a federal, responsibility [82]. Eight of 13 Canadian jurisdictions have instituted mandatory reporting legislation [74].
In Australia, the National Safety and Quality Health Service (NSQHS) Standards include the Preventing and Controlling Infections Standard, which aims to improve infection prevention and control measures to help prevent infections and the spread of antimicrobial resistance [83]. Australia does not, however, have a national HAI surveillance program [84].
CLEANING, DISINFECTION, AND STERILIZATION —
Ensuring the cleanliness of medical equipment and patient care areas are important horizontal measures for prevention and reduction of health care-associated infections (HAIs) [1,2]. In general, the oversight and monitoring of these practices are the joint responsibilities of the infection prevention program and the environmental services department. Personnel from specialized areas (such as operating rooms and intensive care units) also share in these responsibilities at their locations.
Terms used in the following discussion include cleaning, disinfection, and sterilization (table 1):
●Cleaning refers to removal of organic material on soiled surfaces; it is generally accomplished with water, mechanical action, and detergents or enzymatic products [2,85].
●Disinfection refers to the elimination of many or most microorganisms. Chemical disinfectants can kill most vegetative bacteria, some fungi, and some viruses.
●Sterilization refers to complete elimination of all forms of microbial life. Sterilization can be accomplished by either physical or chemical processes; techniques include steam under pressure, dry heat, low temperature sterilization processes (ethylene oxide gas, plasma sterilization), and liquid chemicals [86,87].
Cleaning and disinfection — Environmental cleaning and disinfection reduce organisms transmissible via contact with environmental surfaces; these include methicillin-resistant S. aureus (MRSA), vancomycin-resistant enterococci (VRE), and C. difficile [88-91].
Environmental cleaning is typically followed by disinfection, which eliminates microorganisms [92]. Disinfection in health care settings should be performed with Environmental Protection Agency (EPA)-registered chemicals such as those summarized in the table (table 1) [86,87,93,94]. Data comparing disinfection products are limited [95,96].
For certain situations, specific disinfection protocols are warranted. As an example, disinfection with standard quaternary ammonium-based chemicals does not eliminate bacterial spores (eg, C. difficile) or nonenveloped viruses (eg, norovirus). For disinfection of patient care areas with known or suspected contamination with these pathogens, use of a sporicidal agent (such as bleach) is warranted [97-102]. (See "Clostridioides difficile infection: Prevention and control", section on 'Environmental cleaning and disinfection'.)
Additionally, hospital water is a source of infection transmission [15,17,103]. For example, specific disinfection strategies decrease the risk of transmission from water-containing heater-cooler units; however, full disinfection of faucets and plumbing in patient rooms is typically not feasible [16].
The efficacy of disinfection is affected by several factors [86,104]:
●Physical cleaning prior to disinfection and level of residual organic contamination
●Configuration of surfaces to be cleaned (eg, disinfection of crevices, hinges, and lumens may be more difficult than smooth surfaces)
●Type and level of microbial contamination
●Concentration, temperature and pH of disinfectant
●Exposure time to disinfectant, labeled as the "contact time"
Barriers to effective disinfection include [105,106]:
●Confusion between nursing and environmental services staff over the allocation of cleaning responsibilities
●Insufficient training
●Inadequate time to complete cleaning
●Inappropriate dilution of disinfectant solutions [107]
●Difficulty ensuring disinfection of mobile equipment
●Contamination of reusable cleaning supplies and disinfectant solutions with pathogenic bacteria [107]
●Inability to fully disinfect highly contaminated areas (eg, sinks, plumbing, and water reservoirs) [15]
To overcome these difficulties, infection prevention programs should develop specific policies in collaboration with environmental services teams. In addition, hospitals should implement ongoing training of staff with responsibility for cleaning and disinfection. Consistent results may be achieved by formation of a dedicated cleaning team and implementation of a standardized cleaning and disinfection process [108]. Visual inspection of cleaning and disinfection is not adequate; infection prevention programs must obtain objective data from cleaning and disinfection processes and provide feedback to environmental services with these data [105,109-111].
Systematic execution of such comprehensive infection prevention interventions can reduce the incidence of infections in the health care environment. In a randomized, multicenter trial in 11 Australian hospitals, a multimodal intervention focused on optimization of routine cleaning techniques with staff training and feedback reduced the incidence of VRE infections from 0.35 to 0.22 per 10,000 occupied bed-days (relative risk 0.63, 95% CI 0.41-0.97) [112]. Changes in the incidences of S. aureus and C. difficile infections were not statistically significant. This is consistent with the understanding that the epidemiology of C. difficile infection is more complicated than simple acquisition from the environment. A separate randomized, multicenter trial in 16 United States acute care hospitals concluded that optimized disinfection strategies led to lower rates of C. difficile detection on environmental surfaces but did not impact the rate of hospital-acquired C. difficile infections [113].
No accepted standards exist to establish the cleanliness of a health care environment [106,114,115]. Tools to assess room cleanliness include direct observation, fluorescent markers, and adenosine triphosphate (ATP) bioluminescence. To train cleaning teams, invisible fluorescent markers are applied to surfaces before cleaning; after cleaning, a special light is used to illuminate the surfaces and identify any markers that were missed by the cleaning team [116]. ATP bioluminescence may be used to evaluate for the presence of residual organic material after cleaning, although benchmark standards have not been established [108,117,118]. Cultures are not typically used for routine monitoring of disinfection.
Adjunctive environmental disinfection methods — Technologic advances have led to environmental disinfection methods that augment traditional manual cleaning and disinfection. These new technologies do not replace the need for manual cleaning and disinfection.
Examples include ultraviolet (UV) radiation and hydrogen peroxide (HP) vapor/aerosol. The major advantage of both UV radiation and HP systems are their ability to consistently reduce pathogens on hospital room surfaces. Both systems are residue-free. However, both UV radiation and HP may only be used for terminal disinfection (ie, when patients are not present) and neither can physically clean a room [119].
UV radiation — Ultraviolet (UV) radiation may be a useful adjunctive tool for disinfection, particularly against multidrug-resistant organisms [108,120-127]. In one cluster-randomized crossover study including 21,395 patients (in the intention-to-treat analysis) admitted to rooms from which a patient on contact precautions was discharged, the addition of UV light to disinfection with quaternary ammonium reduced the cumulative incidence of infection or colonization with pathogenic organisms (MRSA, VRE, multidrug-resistant Acinetobacter, and C. difficile) by 30 percent (relative risk 0.70, 95% CI 0.50-0.98; p = 0.036) [120]. No substantial individual decrease in C. difficile infection was observed with the addition of UV light to bleach disinfection (versus bleach alone) for the next patient in the room. However, use of the UV radiation in these targeted rooms did lead to an 11 percent decrease in C. difficile incidence and a 44 percent decrease in VRE incidence for the hospital-wide population [128]. (See "Clostridioides difficile infection: Prevention and control", section on 'Environmental cleaning and disinfection'.)
Another systematic review and meta-analysis including 13 studies evaluating UV systems concluded that UV light no-touch disinfection technology was most effective at preventing C. difficile and VRE [129]. Other than the randomized controlled trial described above, all the studies included in the analysis were quasi-experimental, single-center studies.
Hydrogen peroxide — Hydrogen peroxide (HP) disinfection methods include the use of both vaporized and aerosolized HP. Vaporized HP produces the best log reduction in colony-forming units, achieving essentially complete eradication of experimentally placed bacteria in a test space. Aerosolized HP can produce >5 log reductions in colony-forming units of bacteria, although a wide range (1 to >5) has been reported and there may be unequal dispersion of the aerosols through a space [130].
Medical equipment: Disinfection and sterilization — The type of cleaning, disinfection, and sterilization required depends on the type of medical equipment. Types of medical equipment include the following (table 1) [2]:
●Noncritical equipment – Medical equipment that comes into contact with intact skin but not mucous membranes (eg, stethoscopes, blood pressure cuffs, patient care area surfaces)
●Semicritical equipment – Medical equipment that comes into contact with nonintact skin or mucous membranes (eg, thermometers, endoscopes)
●Critical medical equipment – Medical equipment that comes into contact with sterile tissue or the vascular system (eg, implants, catheters, surgical instruments)
Noncritical medical equipment should be cleaned using a disinfectant that kills most bacteria and some viruses and fungi; cleaning these items with an alcohol wipe between uses is often sufficient [87,93,131,132]. Mobile communication devices such as pagers and cell phones may also become contaminated with bacteria, but effective decontamination of these devices is difficult; hand hygiene immediately prior to patient-contact can remediate the risk to a substantial extent [133,134].
Semicritical medical equipment should be free from all vegetative microorganisms, but small numbers of bacterial spores are permissible since nonintact skin and mucous membranes are generally resistant to infection by spores [2]. Semicritical medical equipment should be cleaned as summarized in the table (table 1).
Critical medical equipment must be sterile because any microbial contamination could transmit disease. These items should be purchased as sterile or be sterilized between uses [2]. Critical medical equipment should be cleaned as summarized in the table (table 1). Disinfection of endoscopes and bronchoscopes is discussed further separately. (See "Preventing infection transmitted by gastrointestinal endoscopy" and "Flexible bronchoscopy in adults: Overview", section on 'Cleaning the bronchoscope'.)
Critical medical equipment used for care of patients with known or suspected disease due to prions (infectious agents composed of protein) requires specific procedures for sterilization. Agents that do not inactivate prions include alcohol, ethylene oxide, formaldehyde, glutaraldehyde, HP, iodine, ionizing radiation, phenolics, quaternary ammonium compounds, steam sterilization (121ºC), or urea (concentration 6 to 8 mol/L) [135]. Issues related to sterilization of prion-contaminated medical equipment are discussed further separately. (See "Creutzfeldt-Jakob disease", section on 'Iatrogenic CJD'.)
SOCIETY GUIDELINE LINKS —
Links to society and government-sponsored guidelines from selected countries and regions around the world are provided separately. (See "Society guideline links: Infection control".)
SUMMARY AND RECOMMENDATIONS
●Overview – Infection prevention programs use protocols and interventions to decrease the risk of infection associated with exposure to health care settings. (See 'Introduction' above.)
●Surveillance and feedback – The cornerstone of successful infection control is effective surveillance, which involves counting cases and calculating rates of infections, with subsequent data reporting to hospital leadership and personnel involved in patient care. (See 'General principles' above and 'Surveillance and feedback' above.)
●Cleaning and disinfection – Cleaning and disinfection of medical equipment and patient care areas are important measures for preventing the transmission of pathogens that may cause infection. (See 'Cleaning, disinfection, and sterilization' above.)
•Patient-care areas – Environmental cleaning refers to the removal of organic material on soiled surfaces of patient care areas; it is typically followed by disinfection, which eliminates microorganisms. Disinfection in health care settings is usually performed with Environmental Protection Agency (EPA)-registered chemicals, such as those summarized in the table (table 1). Special disinfectants are required to eliminate Clostridioides difficile and nonenveloped viruses, such as norovirus. (See 'Cleaning and disinfection' above.)
•Medical equipment – The approach to medical equipment disinfection and sterilization required depends on the equipment type. Types of medical equipment and the approach to disinfection and sterilization are summarized in the table (table 1). (See 'Medical equipment: Disinfection and sterilization' above.)
•Training of cleaning staff – Hospitals should implement ongoing training and retraining of staff with responsibility for cleaning and disinfection, together with monitoring and feedback. Consistent results may be achieved by formation of a dedicated cleaning team and implementation of a standardized cleaning process. (See 'Cleaning and disinfection' above.)
