This nomogram applies to warfarin initial dosing in an otherwise healthy adult without comorbidities that could affect warfarin metabolism. Evidence to support this nomogram was derived in a young, mostly male population with venous thromboembolism. Lower initial dosing may be appropriate for individuals who are frail, elderly, or malnourished; who have liver or kidney disease or heart failure; or who are receiving a medication known to increase warfarin sensitivity. Higher initial dosing may be appropriate for individuals who were previously receiving warfarin and had higher dose requirements. Refer to UpToDate topics on the use of warfarin and specific clinical indications for further details.