Version May 2024
Peripheral vascular disorders: Oral: 12 to 48 mg daily in 3 to 4 divided doses.
Organic mental disorders: Oral: 12 to 24 mg daily in 3 to 4 divided doses.
No dosage adjustment provided in manufacturer’s labeling.
No dosage adjustment provided in manufacturer’s labeling.
Refer to adult dosing.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Frequency not defined.
Cardiovascular: Orthostatic hypotension, palpitations
Central nervous system: Dizziness, nervousness
Gastrointestinal: Nausea, vomiting
Hypersensitivity: Hypersensitivity reaction
Neuromuscular & skeletal: Tremor, weakness
Acute myocardial infarction; paroxysmal tachycardia; progressive angina pectoris; thyrotoxicosis
Disease-related concerns:
• Cardiovascular disease: Use caution in patients with cardiovascular disease.
Other warnings/precautions:
• Appropriate use: Organic mental disorder: Diagnosis should be established and reversible and/or treatable conditions ruled out prior to initiating therapy; not indicated for use in patients experiencing normal aging symptoms or with presenile dementia.
Yes
Considered “possibly effective” for increasing blood supply to treat peripheral disease (arteriosclerosis obliterans, thromboangiitis obliterans, diabetic vascular disease, nocturnal leg cramps, Raynaud's disease, frost bite, ischemic ulcer, thrombophlebitis) and for mild-to-moderate symptoms associated with organic mental disorders
None known.
There are no known significant interactions.
Animal reproduction studies have not been conducted. Nylidrin has been evaluated for use as a tocolytic (Kurki, 1991).
It is not known if nylidrin is excreted in breast milk. Breast-feeding is not recommended by the manufacturer.
Nylidrin is a peripheral vasodilator; this results from direct relaxation of vascular smooth muscle and beta-agonist action. Nylidrin does not appear to affect cutaneous blood flow; it reportedly increases blood flow to ischemic tissues with minimal blood pressure changes and increases cardiac output
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