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Oxygen: Drug information

Oxygen: Drug information
For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Pharmacologic Category
  • Dental Gases
Dosing: Adult

Children and Adults: Average rate of 2 L/minute

Dosing: Older Adult

Refer to adult dosing.

Dosing: Pediatric

Refer to adult dosing.

Adverse Reactions

No data reported

Contraindications

No data reported

Warnings/Precautions

Concerns related to adverse effects:

• Hypoventilation: Oxygen-induced hypoventilation is the greatest potential hazard of oxygen therapy. In patients with severe COPD, the respiratory drive results from hypoxic stimulation of the carotid chemoreceptors. If this hypoxic drive is diminished by excessive oxygen therapy, hypoventilation may occur and further carbon dioxide retention with possible cessation of ventilation.

• Pulmonary fibrosis: Extended exposure to higher O2 concentrations has been associated with pulmonary fibrosis.

Generic Equivalent Available: US

May be product dependent

Dosage Forms: Canada

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Gas, Inhalation:

Generic: 99% (1 ea); 99.5% (1 ea); 99.99% (1 ea)

Use: Labeled Indications

Treatment of various clinical disorders, both respiratory and nonrespiratory; relief of arterial hypoxia and secondary complications; treatment of pulmonary hypertension, polycythemia secondary to hypoxemia, chronic disease states complicated by anemia, cancer, migraine headaches, coronary artery disease, seizure disorders, sickle-cell crisis, and sleep apnea

Metabolism/Transport Effects

None known.

Drug Interactions

Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the Lexicomp drug interactions program by clicking on the “Launch drug interactions program” link above.

Amiodarone: Oxygen may enhance the adverse/toxic effect of Amiodarone. Specifically, amiodarone pulmonary toxicity may be enhanced. Risk C: Monitor therapy

Bleomycin: Oxygen may enhance the adverse/toxic effect of Bleomycin. Specifically, bleomycin pulmonary toxicity may be enhanced. Management: Attempt to keep oxygen at a concentration equal to that of room air (eg, 25%), during surgery and the post-operative period for patients receiving bleomycin. Monitor patients carefully for pulmonary toxicity, especially those receiving fluid replacement. Risk D: Consider therapy modification

Mechanism of Action

Increased oxygen in tidal volume and oxygenation of tissues at molecular level

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (BE) Belgium: Keol c | Oxygene gazeux air liquid medical | Oxygene gazeux air products | Oxygene gazeux btg - gtb | Oxygene gazeux hoekloos | Oxygene gazeux ijsfabriek stromb. | Oxygene gazeux messer | Oxygene liquid air liquid medical | Oxygene liquid btg - gtb | Oxygene liquide air products | Oxygene liquide messer | Oxygene Medicinal Gazeux Praxair;
  • (CO) Colombia: Aire | Aire medicinal | Aire medicinal comprimido | Oxigeno | Oxigeno medicinal | Oximed;
  • (DE) Germany: Gox sauerstoff;
  • (ES) Spain: Aire medicinal sintetico contse;
  • (FI) Finland: Conoxia;
  • (GB) United Kingdom: Liquid oxygen | Medical Liquid Oxygen | O pur oxygen;
  • (HR) Croatia: Medicinski kisik;
  • (ID) Indonesia: Oxycan;
  • (IT) Italy: Ossigeno | Ossigeno euroxan | Oxo | Sanoxygen;
  • (MX) Mexico: Oxigeno medicinal;
  • (NO) Norway: Medisinsk luft Praxair | Medisinsk oksygen | Medisinsk oksygen Praxair;
  • (RU) Russian Federation: Medical gaseous oxygen;
  • (SE) Sweden: Medicinsk luft aga | Medicinsk luft air liquide | Medicinsk oxygen | Medicinsk oxygen aga;
  • (ZW) Zimbabwe: Afrox compressed medical oxygen
Topic 10185 Version 72.0

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