Version July 2025
Congenital sucrase-isomaltase deficiency (CSID): Oral: 17,000 units (2 mL) per meal or snack.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
Refer to adult dosing.
(For additional information see "Sacrosidase: Pediatric drug information")
Congenital sucrose-isomaltase deficiency or sucrase deficiency:
Note: Approximately half of the dose should be administered before the meal or snack and the remainder administered during the meal or snack. Dose may be measured by volume (mL) or drop count method from the Sucraid container tip in which case 1 mL = 28 drops.
Infants ≥5 months and Children ≤15 kg: Oral: 8,500 units (1 mL = 28 drops from Sucraid container tip) per meal or snack (Ref).
Children >15 kg and Adolescents: Oral: 17,000 units (2 mL = 56 drops from Sucraid container tip) per meal or snack.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
1% to 10%:
Endocrine & metabolic: Dehydration
Gastrointestinal: Abdominal pain, constipation, diarrhea, nausea, vomiting
Nervous system: Headache, insomnia, nervousness
Postmarketing:
Dermatologic: Allergic skin reaction
Hypersensitivity: Hypersensitivity reaction
Hypersensitivity to yeast, yeast products, glycerin (glycerol), or papain
Concerns related to adverse effects:
• Hypersensitivity reactions: Hypersensitivity reactions to sacrosidase, including pruritus, rash, and wheezing, have been reported; cutaneous hypersensitivity may also occur. Discontinue sacrosidase and seek medical attention if hypersensitivity reactions occur.
Disease-related concerns:
• Diabetes mellitus: Use with caution in patients with diabetes; sacrosidase enables absorption of fructose and glucose.
Dosage form specific issues:
• Papain: Product may contain papain. Severe hypersensitivity reactions, including anaphylaxis, have been observed with papain exposure.
Other warnings/precautions:
• Congenital sucrase-isomaltase deficiency diagnostic test: The definitive test for diagnosis of congenital sucrase-isomaltase deficiency is by the measurement of intestinal disaccharidases following small bowel biopsy; other tests (eg, breath hydrogen test, oral sucrose tolerance test) have a high incidence of false negatives/positives. Differential urinary disaccharide testing has shown good agreement with small intestinal biopsy.
• Dietary starch restriction: Consider restricting dietary starch (especially in patients not adequately controlled by sacrosidase); sacrosidase does not replace isomaltase and patient may still experience congenital sucrase-isomaltase deficiency symptoms while taking sacrosidase.
Oral solution contains 50% glycerol.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Solution, Oral:
Sucraid: 8500 units/mL (2 mL, 118 mL [DSC]) [contains papain]
No
Solution (Sucraid Oral)
8500 units/mL (per mL): $48.22
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
Sucraid is not available in retail pharmacies or via mail-order pharmacies. To obtain the product, please refer to http://www.sucraid.net/how-to-order-sucraid or call 1-866-740-2743.
Oral: Dilute dose in 120 mL of cold or room temperature water or milk and mix well; avoid dissolving in fruit juices or warm or hot food/liquids. Administer one-half of dose at beginning of each meal and snack and remainder during meal or snack. Measure dosage from multiple-dose bottle with measuring scoop provided or by drop count method (1 mL equals 28 drops from the bottle tip); also available as 2 mL single-use container.
Oral: Oral solution: Dilute dose prior to administration; dilution volume depends on dose. Administer 1/2 of the dose before each meal or snack, and the remainder of the dose during the meal or snack; this may help to preserve sacrosidase activity and allow for better sucrose absorption. Do not administer with fruit juices (acidic environment may reduce enzyme activity) or warm or hot food/liquids (heat may lower potency of enzyme).
Dilution of dose:
1 mL (8,500 unit) dose:
Multidose bottle: Measure 1 scoop (provided) or 28 drops; dilute dose in 60 mL of cold or room temperature water, milk, or infant formula; liquid should not be warmed or heated after sacrosidase added. Rinse measuring scoop with water after use.
2 mL (17,000 unit) dose:
Multidose bottle: Measure 2 scoops (provided) or 56 drops; dilute dose in 120 mL of cold or room temperature water, milk, or formula; liquid should not be warmed or heated after sacrosidase added. Rinse measuring scoop with water after use.
Single-use 2 mL container: Empty entire contents of container into 120 mL of cold or room temperature water, milk, or formula; liquid should not be warmed or heated after sacrosidase added.
Congenital sucrase-isomaltase deficiency: Treatment of sucrase deficiency, as seen in congenital sucrase-isomaltase deficiency, in pediatric patients ≥5 months of age and adults.
None known.
There are no known significant interactions.
May be inactivated or denatured if administered with fruit juice or warm or hot food/liquids. Isomaltase deficiency is not addressed by supplementation of sacrosidase. Management: Administer with 2-4 oz of water, milk, or formula. Because isomaltase deficiency is not addressed by supplementation of sacrosidase, adherence to a low-starch diet may be required.
Animal reproduction studies have not been conducted. Use is not expected to cause fetal harm when used during pregnancy; administer to a pregnant woman only when indicated.
Sacrosidase is broken down in the stomach and intestines and the component amino acids and peptides are then absorbed as nutrients.
Do not take with fruit juices. Because isomaltase deficiency is not addressed by supplementation of sacrosidase, adherence to a low-starch diet may be required.
Hypersensitivity reactions, diarrhea, abdominal pain, gas, and abdominal distention/bloating from excessive fermentation of undigested carbohydrates.
Sacrosidase is a naturally-occurring gastrointestinal enzyme derived from baker's yeast (Saccharomyces cerevisiae) which breaks down the disaccharide sucrose to its monosaccharide components. Hydrolysis is necessary to allow absorption of these nutrients.
Absorption: Amino acids
Metabolism: GI tract to individual amino acids
