Vitamin K is a cofactor in the post-translational modification of coagulation factors in the liver. FFP and PCC provide coagulation factors (refer to UpToDate content for specific constituents in PCC). rFVIIa is a procoagulant. Cryoprecipitate provides fibrinogen. DDAVP can stimulate release of von Willebrand factor to counteract platelet dysfunction. Antifibrinolytics promote clot stability. Refer to UpToDate topics on hemostatic abnormalities in patients with liver disease for further details and indications for these interventions.
Adapted by permission from Macmillan Publishers Ltd: Nature Reviews Gastroenterology and Hepatology. Shah NL, Intagliata NM, Northup PG, et al. Procoagulant therapeutics in liver disease: a critique and clinical rationale. Nat Rev Gastroenterol Hepatol 2014; 11:678. Copyright © 2014.
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