Comparison of Fresh Frozen Plasma and Cryoprecipitate

Values for fibrinogen are approximate, per one unit of each component. FFP contains coagulation factors at the same concentration present in plasma. Cryoprecipitate is a highly concentrated source of fibrinogen. Cryoprecipitate also contains factor XIII, von Willebrand factor (vWF), and factor VIII; however, it is not used to replace these factors because factor concentrates and recombinant products with better safety profiles are available. The cost per unit of fibrinogen is similar in FFP and Cryoprecipiate. In severe liver disease, pools of 8 to 10 units of Cryoprecipitate may be used so the total cost (and amount of fibrinogen given) may be greater. Refer to UpToDate topics on plasma components and specific uses of these products for indications and further details.