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Triclosan and fluoride (dental): Drug information

Triclosan and fluoride (dental): Drug information
For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: US
  • Colgate Total
Pharmacologic Category
  • Antibacterial, Dental;
  • Mineral, Oral, Topical
Dosing: Adult
Prevention of dental caries and gingivitis

Prevention of dental caries and gingivitis: Oral: Brush teeth thoroughly after each meal or at least twice daily.

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in the manufacturer’s labeling.

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer’s labeling.

Dosing: Older Adult

Refer to adult dosing.

Dosing: Pediatric
Prevention of dental caries and gingivitis

Prevention of dental caries and gingivitis: Children ≥6 years and Adolescents: Refer to adult dosing

Adverse Reactions

There are no adverse reactions listed in the manufacturer's labeling. See Fluoride monograph.

Warnings/Precautions

Special populations:

• Pediatric: Antigingivitis and antiplaque effects have not been determined in children <6 years of age.

Other warnings/precautions:

• Accidental ingestion: If an amount greater than used for brushing is swallowed, seek professional assistance of contact a poison control center immediately.

• Self-medication (OTC use): Patients should consult healthcare provider or dentist prior to use if experiencing oral pain, swelling, pus, loose teeth, increased spacing between teeth, or if experiencing oral bleeding or redness lasting longer than 2 weeks.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Gel, oral [toothpaste]: Triclosan 0.30% and sodium fluoride 0.24% (119 g, 170 g, 221 g)

Paste, oral [toothpaste]: Triclosan 0.30% and sodium fluoride 0.24% (119 g, 170 g, 221 g)

Generic Equivalent Available: US

No

Administration: Adult

Oral: Apply a pea-sized amount of paste/gel to a soft bristle toothbrush. Brush for at least 2 minutes after each meal or at a minimum twice daily.

Administration: Pediatric

Oral: Apply a pea-sized amount of paste/gel to a soft bristle toothbrush. Brush for at least 2 minutes after each meal or at a minimum twice daily. Supervise children and instruct on good brushing and rinsing habits to minimize swallowing.

Use: Labeled Indications

Dental caries and gingivitis: Used exclusively in dental applications for the prevention of cavities, plaque, and gingivitis.

Metabolism/Transport Effects

None known.

Drug Interactions

There are no known significant interactions.

Pregnancy Considerations

Refer to fluoride monograph.

Breastfeeding Considerations

Refer to fluoride monograph.

Mechanism of Action

Triclosan is an antibacterial agent which helps to prevent gingivitis with regular use. Fluoride promotes remineralization of decalcified enamel, inhibits the cariogenic microbial process in dental plaque, and increases tooth resistance to acid dissolution

  1. Colgate Total (triclosan and fluoride) [product labeling]. New York, NY: Colgate-Palmolive Co; September 2010.
  2. Rosling B, Wannfors B, Volpe AR, et a, “The Use of a Triclosan/Copolymer Dentifrice May Retard the Progression of Periodontitis,” J Clin Periodontol, 1997, 24:873-80. [PubMed 9442423]
Topic 10299 Version 68.0

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