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Potassium p-aminobenzoate: Drug information

Potassium p-aminobenzoate: Drug information
(For additional information see "Potassium p-aminobenzoate: Patient drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: US
  • Potaba [DSC]
Pharmacologic Category
  • Vitamin, Water Soluble
Dosing: Adult
Skin conditions

Skin conditions:

Oral: Average dose: 12 g/day in 4 to 6 divided doses; may take 2 to 3 months before results are noticeable.

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in manufacturer's labeling; use with caution.

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in manufacturer's labeling.

Dosing: Older Adult

Refer to adult dosing.

Dosing: Pediatric
Skin conditions

Skin conditions: Oral: 1 g/10 pounds of weight/day; administer in divided doses.

Dosing: Kidney Impairment: Pediatric

There are no dosage adjustments provided in manufacturer’s labeling. Use with caution.

Dosing: Hepatic Impairment: Pediatric

There are no dosage adjustments provided in manufacturer’s labeling.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Frequency not defined.

Dermatologic: Skin rash

Gastrointestinal: Anorexia, nausea

Hypersensitivity: Hypersensitivity reaction

Miscellaneous: Fever

Contraindications

Concurrent use of sulfonamides.

Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.

Warnings/Precautions

Concerns related to adverse effects:

• Anorexia: Interrupt therapy if anorexia occurs; may reinstitute once patient improves.

• Nausea: Interrupt therapy if nausea occurs; may reinstitute once patient improves.

Disease-related concerns:

• Diabetes: Use with caution in patients with diabetes mellitus or a history of hypoglycemia.

• Renal impairment: Use with caution in patients with renal impairment.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Capsule, Oral:

Potaba: 500 mg [DSC]

Generic Equivalent Available: US

No

Pricing: US

Capsules (Potaba Oral)

500 mg (per each): $0.91

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Administration: Adult

Oral: Administer with a glass of water after meals and at bedtime with a snack; also refer to manufacturer’s labeling.

Administration: Pediatric

Oral: Administer with a glass of water after meals or with a snack.

Use: Labeled Indications

Skin conditions: Presently, all indications are classified by the FDA as "possibly effective."

Treatment of scleroderma, dermatomyositis, morphea, linear scleroderma, pemphigus, Peyronie disease.

Metabolism/Transport Effects

None known.

Drug Interactions

Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the Lexicomp drug interactions program by clicking on the “Launch drug interactions program” link above.

Sulfonamide Antibiotics: Potassium P-Aminobenzoate may diminish the therapeutic effect of Sulfonamide Antibiotics. Risk X: Avoid combination

Pregnancy Considerations

Safety for use in pregnancy has not been established.

Breastfeeding Considerations

According to the manufacturer, safety for use in nursing women has not been established.

Dietary Considerations

Take with food to avoid stomach upset.

Mechanism of Action

P-aminobenzoate is a member of the vitamin B complex family. It may have an antifibrotic effect due to increased oxygen uptake at the tissue level.

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (CH) Switzerland: Potaba-glenwood;
  • (DE) Germany: Potaba-glenwood;
  • (EE) Estonia: Potaba;
  • (ES) Spain: Fibroderm;
  • (GB) United Kingdom: Potaba;
  • (IE) Ireland: Potaba;
  • (KR) Korea, Republic of: Peyret | Peyron;
  • (PR) Puerto Rico: Aminobenzoate potassium | Potaba
  1. Potaba (potassium p-aminobenzoate) [prescribing information]. Englewood, NJ: Glenwood LLC; March 2009.
Topic 10308 Version 104.0

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