Skin findings in diffuse cutaneous mastocytosis

The skin of this infant demonstrates typical findings of diffuse cutaneous mastocytosis. These include leathery, thickening of the skin (peau d'orange) and multiple nodules (A); exaggerated skin folds in the neck (B) and under the arm (C). Spontaneous Darier's sign (urtication of a lesion after friction) can be seen in the neck area (B) and left chest area (C). A mastocytoma (aggregation of a large number of mast cells) in the temporo-occipital area (D).