Version May 2024
Hemorrhoids, anorectal pain/itch:
Note: Combine with dietary modifications, bowel hygiene, and warm sitz baths for best results (ASCRS [Davis 2018]; Brown 2022). General dosing guidelines provided; refer to specific product labeling for dosing instructions.
Suppository: Rectal: Insert 1 suppository, as needed, up to 6 times daily or after each bowel movement.
Protectant: Topical: Apply as required to affected areas several times daily
There are no dosage adjustments provided in the manufacturer’s labeling.
There are no dosage adjustments provided in the manufacturer’s labeling.
Refer to adult dosing.
(For additional information see "Zinc oxide: Pediatric drug information")
Note: Approved uses and ages for pediatric patients may vary by product; consult product-specific labeling.
Hemorrhoids: Children ≥12 years and Adolescents: Suppository: Rectal: Insert 1 suppository up to 6 times daily or after each bowel movement.
Skin protectant:
Infants, Children, and Adolescents: Topical:
Cream, ointment, paste, stick: Apply generously to affected area as needed, especially with each diaper change or after incontinence episodes if applicable.
Powder: Apply as needed.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
1% to 10%:
Hypersensitivity: Local hypersensitivity reaction
Local: Local irritation
Other warnings/precautions:
• Appropriate use: Notify health care provider if condition worsens or does not improve within 7 days or if bleeding occurs.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Aerosol, topical:
Dr. Smith's Diaper Rash: 10% (100 g [DSC]) [contains methylparaben, polysorbate 80, propylene glycol, and propylparaben]
Dr. Smith's Adult Barrier: 10% (100 g, 170 g) [contains methylparaben, polysorbate 80, propylene glycol, and propylparaben]
Cream, topical:
Balmex: 11.3% (60 g, 120 g, 480 g) [contains aloe, benzoic acid, soybean oil, and vitamin E]
Baza Protect Moisture Barrier: 12% (57 g, 142 g) [contains cetyl alcohol, edetate disodium, propylene glycol]
Desitin Rapid Relief: 13% (57 g, 113 g, 454 g) [contains methylparaben and propylparaben]
Secura Protective: 10% (78 g) [contains methylparaben]
Cream, topical [stick]:
Balmex: 11.3% (56 g) [contains aloe, benzoic acid, soybean oil, and vitamin E]
Ointment, topical:
AmeriDerm PeriShield: 3.8% (100 g)
Boudreaux's Butt Paste: 16% (57 g, 113 g, 454 g); 40% (57g, 113 g, 397 g)
CareAll: 20% (28 g, 56 g, 425 g)
Dr. Smith's Adult Barrier [OTC]: 10% (85 g)
Dr. Smith's Diaper Rash: 10% (57 g, 85 g, 227 g)
Medpura: 20% (56.7 g, 85 g, 454 g)
PeriGuard: 3.8% (100 g [DSC])
Pharmabase Barrier: 9.38% (500 g)
Generic: 20% (30 g, 60 g, 454 g); 40% (120 g)
Paste, topical:
Calazime Skin Protectant: 16.5% (113 g [DSC]) [contains calamine, menthol]
Critic-Aid Thick Moist Barrier: 20% (71 g, 170 g)
Desitin Maximum Strength Original: 40% (28 g, 57 g, 85 g, 120 g, 113 g, 454 g) [contains cod liver oil and lanolin]
GoodSense Diaper Rash [OTC]: 40% (56.7 g) [contains methylparaben]
Triple Paste: 12.8% (57 g, 454 g, 227 g)
Z-Guard: 17% (113 g) [contains petrolatum 57% and soy protein]
Powder, topical:
Ammens Original Medicated: 9.1% (312 g)
Ammens Shower Fresh: 9.1% (312 g)
Suppository, rectal:
Calmol 4: 10% (12s, 24s)
Yes: Ointment
Cream (Baza Protect Moisture Barrier External)
12% (per gram): $0.08
Cream (Secura Protective External)
10% (per gram): $0.10
Cream (Z-Bum External)
22% (per gram): $0.43
Ointment (AmeriDerm PeriShield External)
3.8% (per gram): $0.02
Ointment (Boudreauxs Butt Paste External)
16% (per gram): $0.08
40% (per gram): $0.09
Ointment (Dr Smiths Diaper External)
10% (per gram): $0.07
Ointment (Medpura Zinc Oxide External)
20% (per gram): $0.04
Ointment (Pharmabase Barrier External)
9.38% (per gram): $2.60
Ointment (Zinc Oxide External)
20% (per gram): $0.06 - $0.15
25% (per gram): $0.02
Paste (Desitin External)
40% (per gram): $0.11
Paste (Zinc Oxide External)
25% (per gram): $0.14
Suppository (Calmol-4 Rectal)
76-10% (per each): $0.74
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
May stain clothing and fabric.
Rectal (suppository): For rectal use only. Gently cleanse and dry anorectal area, if possible, prior to inserting suppository. Remove suppository from wrapper and insert bulb shape first into rectum.
Topical: For external use only; do not apply to eyes. Gently cleanse and dry the affected area. Apply liberally.
Rectal: Suppository: Gently cleanse and dry anorectal area, if possible, prior to inserting suppository. Remove suppository from wrapper and insert bulb shape first into rectum.
Topical:
Cream, paste, stick: For external use only; do not use in the eyes. Gently cleanse affected area and pat dry with a clean, soft cloth or allow to air dry. May use dry tissue to remove excess product.
Powder: For external use only; avoid contact with eyes and face or mouth (to avoid breathing in powder). Do not use on broken skin.
Hemorrhoids, anorectal pain/itch: Temporary relief of burning, irritation, itching, and discomfort associated with hemorrhoids; protects inflamed, irritated anorectal surface to help make bowel movements less painful.
Protectant (topical products): Protective coating for mild skin irritations, poison ivy, poison oak, poison sumac, and abrasions; soothing and protective ointment to promote healing of chapped skin, diaper rash.
None known.
There are no known significant interactions.
Zinc oxide is not expected to be absorbed systemically following topical administration to healthy skin (Newman, 2009). Systemic absorption would be required in order for zinc oxide to cross the placenta and reach the fetus.
Mild astringent with weak antiseptic properties
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