Version May 2024
Surgical aid: Ophthalmic:
Cataract surgery: 0.06% solution (VisionBlue): Apply onto anterior lens capsule using a blunt cannula.
Vitrectomy surgery: 0.15% solution (MembraneBlue): Apply to epiretinal membranes using a blunt cannula after fluid-air exchange or inject directly in a balanced salt solution-filled vitreous cavity.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
Refer to adult dosing.
Surgical aid: Children and Adolescents: Ophthalmic: Topical: Refer to adult dosing.
There are no dosage adjustments provided in the manufacturer’s labeling.
There are no dosage adjustments provided in the manufacturer’s labeling.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
Frequency not defined: Ophthalmic: Ocular discoloration (inadvertent staining of posterior lens and vitreous face; staining may last up to 1 week)
Use when a nonhydrated (dry state), hydrophilic acrylic intraocular lens (IOL) insertion is planned (potential for the dye to be absorbed by and stain the IOL)
Other warnings/precautions:
• Administration: MembraneBlue: Prime the syringe by retracting plunger or twist plunger with a clockwise motion before injection; ensure the syringe plunger moves smoothly prior to use.
• Appropriate use: Remove excess dye after use to prevent excessive staining.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Solution Prefilled Syringe, Intraocular:
MembraneBlue: 0.15% (0.5 mL [DSC])
VisionBlue: 0.06% (0.5 mL)
No
Solution Prefilled Syringe (VisionBlue Intraocular)
0.06% (per 0.5 mL): $91.56
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution Prefilled Syringe, Intraocular:
Vision Blue: 0.06% (0.5 mL)
Ophthalmic: Topical:
0.06% solution (VisionBlue): To minimize dilution of the dye (trypan blue) by the aqueous, an air bubble should be injected into the anterior chamber of the eye after opening the eye, but prior to application of trypan blue. Irrigate with balanced salt solution to remove excess dye.
0.15% solution (MembraneBlue): Ensure that the plunger moves smoothly before use. Prime the syringe prior to injecting the fluid. Alternatively, twist the plunger into the stopper in a clockwise motion until tight. Once tight, continue turning the plunger in a clockwise motion until the stopper rotates freely in the syringe (2 or 3 rotations). If applying to epiretinal membranes, must perform a fluid-air exchange prior to injection of trypan blue to prevent aqueous dilution of the dye; immediately remove all excess dye following injection. If injecting directly into a balanced salt solution filled-vitreous cavity, wait 30 seconds following injection (sufficient staining is achieved after 30 seconds), then remove all excess dye.
Ophthalmic: Topical:
Trypan blue 0.06% (VisionBlue): To minimize dilution of the dye (trypan blue) by the aqueous, an air bubble should be injected into the anterior chamber of the eye after opening the eye, but prior to application of trypan blue. Irrigate with balanced salt solution to remove excess dye.
Trypan blue 0.15% (MembraneBlue): Ensure that the plunger moves smoothly before use. Prime the syringe prior to injecting the fluid. Alternatively, twist the plunger into the stopper in a clockwise motion until tight. Once tight, continue turning the plunger in a clockwise motion until the stopper rotates freely in the syringe (two or three rotations). If applying to epiretinal membranes, must perform a fluid-air exchange prior to injection of trypan blue to prevent aqueous dilution of the dye; immediately remove all excess dye following injection. If injecting directly into a balanced salt solution filled-vitreous cavity, wait 30 seconds following injection (sufficient staining is achieved after 30 seconds), then remove all excess dye.
Surgical aid (ophthalmic):
0.06% solution (VisionBlue): Stains the anterior capsule of the lens in cataract surgery.
0.15% solution (MembraneBlue): Stains the epiretinal membranes, facilitating removal of the tissue during vitrectomy procedures.
VisionBlue may be confused with methylene blue
Adverse events were observed in animal reproduction studies.
Systemic exposure is negligible following ophthalmic use as recommended.
It is not known if trypan blue is present in breast milk.
Systemic exposure is negligible following ophthalmic use as recommended.
An acid di-azo group dye that selectively stains connective tissue structures and epiretinal membranes in the human eye, facilitating visualization during ophthalmic surgery.
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