Simplified immune synapse for an anergic CD8 T cell

In the absence of the "second signal," which in the naïve T cell is CD28 but in activated T cells can be OX40, CD137, etc, T cells can become anergic and do not mount a response to antigen.

CD: cluster of differentiation; APC: antigen-presenting cells; MHC: major histocompatibility complex.

Graphic 103339 Version 1.0

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