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تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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PD-1-PD-L1 binding leads to peripheral CD8+ T cell "exhaustion" phenotype

PD-1-PD-L1 binding leads to peripheral CD8+ T cell "exhaustion" phenotype
In a state of chronic antigen presentation, such as malignancy, the chronic presence of antigen or pro-inflammatory cytokines (IL-12, IFNgamma, etc) can upregulate PD-1 expression on the T cell; tumor clones can also select for PD-L1 expression. With PD-1-PD-L1 binding, even in the presence of the costimulatory molecule, "peripheral exhaustion" can occur.
PD-L1: programmed death-ligand 1; CD: cluster of differentiation; PD-1: programmed cell death-1; APC: antigen-presenting cells; MHC: major histocompatibility complex; IL: interleukin; IFNgamma: interferon gamma.
Graphic 103341 Version 2.0

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