Version July 2025
Medical food: Oral: 7.5 to 15 mg daily.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
Refer to adult dosing.
There are no adverse reactions listed in the manufacturer's labeling.
Hypersensitivity to any component of the formulation
Disease-related concerns:
• Anemia: Monotherapy: Not appropriate for monotherapy with pernicious or other megaloblastic anemias when anemia is present with vitamin B12 deficiency.
• Pernicious anemia: Doses >0.1 mg/day may obscure pernicious anemia with continuing irreversible nerve damage progression.
Other warnings/precautions:
• Medicinal food: Product is a medicinal food for use only under the supervision of a health care provider.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Capsule, Oral:
Denovo: 15 mg [contains fd&c yellow #5 (tartrazine), fd&c yellow #6 (sunset yellow)]
Deplin 7.5: L-methylfolate 7.5 mg and Schizochytrium algae [contains fd&c red #40 (allura red ac dye), fd&c yellow #6 (sunset yellow), fd&c yellow #6(sunset yellow)alumin lake, sodium caseinate, soy protein, soybean lecithin]
Deplin 15: L-methylfolate 15 mg and Schizochytrium algae [contains fd&c red #40 (allura red ac dye), fd&c yellow #6 (sunset yellow), sodium caseinate, soy protein, soybean lecithin]
L-Methylfolate Forte: L-methylfolate 15 mg and Schizochytrium algae [contains carmine (cochineal extract), sodium caseinate, soy protein, soybean lecithin]
L-Methylfolate Forte: L-methylfolate 7.5 mg and Schizochytrium algae [contains fd&c red #40 (allura red ac dye), fd&c yellow #6 (sunset yellow), fd&c yellow #6(sunset yellow)alumin lake, sodium caseinate, soy protein, soybean lecithin]
Generic: L-methylfolate 15 mg and Schizochytrium algae
Capsule, Oral [preservative free]:
Deplin FC: 7.5 mg, 15 mg [dye free, egg free, fish derivative free, milk free, peanut free, sesame free, shellfish free, sodium free, soy free, sugar free, tree nut free, wheat free]
Tablet, Oral:
Elfolate: 7.5 mg, 15 mg
Generic: 7.5 mg, 15 mg
Yes
Capsules (Deplin 15 Oral)
15-90.314 mg (per each): $7.91
Capsules (Deplin 7.5 Oral)
7.5-90.314 mg (per each): $7.91
Capsules (Deplin FC Oral)
7.5 mg (per each): $7.91
15 mg (per each): $7.91
Capsules (L-Methylfolate-Algae Oral)
15-90.314 mg (per each): $4.06
Tablets (Elfolate Oral)
7.5 mg (per each): $4.32
15 mg (per each): $4.32
Tablets (L-Methylfolate Oral)
7.5 mg (per each): $2.89 - $2.96
15 mg (per each): $2.89 - $2.96
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
Oral: May be administered with or without food.
Medical food: Medical food for the nutritional requirements of patients with suboptimal L-methylfolate and who have major depressive disorder or schizophrenia.
Note: A medical food is formulated to be administered enterally under the supervision of a physician and is intended for the specific dietary management of a disease or condition for which distinctive nutritional requirements are established by medical evaluation. Medical foods are not drugs and, therefore, are not subject to any FDA regulatory requirements that specifically apply to drugs (eg, requirement for written/oral prescription prior to dispensing, premarket review or approval, proof of safety and efficacy).
None known.
Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program by clicking on the “Launch drug interactions program” link above.
Fluorouracil Products: Folic Acid may increase adverse/toxic effects of Fluorouracil Products. Risk C: Monitor
Fosphenytoin-Phenytoin: Folic Acid may decrease serum concentration of Fosphenytoin-Phenytoin. Risk C: Monitor
Green Tea: May decrease serum concentration of Folic Acid. Risk C: Monitor
Pafolacianine: Coadministration of Folic Acid and Pafolacianine may alter diagnostic results. Risk X: Avoid
PHENobarbital: Folic Acid may decrease serum concentration of PHENobarbital. Risk C: Monitor
Primidone: Folic Acid may decrease serum concentration of Primidone. Additionally, folic acid may decrease concentrations of active metabolites of primidone (e.g., phenobarbital). Risk C: Monitor
Pyrimethamine: Folic Acid may decrease therapeutic effects of Pyrimethamine. Management: Folic acid doses greater than 2.5 mg per day should be avoided due to the potential for sulfadoxine/pyrimethamine treatment failure. Consider limiting folic acid use to no more than 0.4 mg per day for women of child-bearing age. Risk D: Consider Therapy Modification
Raltitrexed: Folic Acid may decrease therapeutic effects of Raltitrexed. Risk X: Avoid
Sulfadoxine: Folic Acid may decrease therapeutic effects of Sulfadoxine. Management: Folic acid doses greater than 2.5 mg per day should be avoided due to the potential for sulfadoxine/pyrimethamine treatment failure. Consider limiting folic acid use to no more than 0.4 mg per day for women of child-bearing age. Risk D: Consider Therapy Modification
SulfaSALAzine: May decrease serum concentration of Folic Acid. Risk C: Monitor
Methylfolate, or L-methylfolate, is the active form of folate in the body, which can be transported into peripheral tissues and across the blood-brain barrier. Folate is necessary for formation of numerous coenzymes in many metabolic systems, particularly for purine, pyrimidine, and nucleoprotein synthesis, and maintenance in erythropoiesis; stimulates WBC and platelet production in folate deficiency anemia.
