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Bacitracin and polymyxin B (topical): Drug information

Bacitracin and polymyxin B (topical): Drug information
(For additional information see "Bacitracin and polymyxin B (topical): Patient drug information" and see "Bacitracin and polymyxin B (topical): Pediatric drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: US
  • Double Antibiotic [OTC];
  • Polysporin [OTC]
Pharmacologic Category
  • Antibiotic, Topical
Dosing: Adult
Topical infection prevention

Topical infection prevention: Topical: Apply to affected area 1 to 3 times/day; may cover with sterile bandage if needed.

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to low systemic absorption.

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to low systemic absorption.

Dosing: Older Adult

Refer to adult dosing.

Dosing: Pediatric

(For additional information see "Bacitracin and polymyxin B (topical): Pediatric drug information")

Prevention of infection

Prevention of infection: Infants, Children, and Adolescents: Topical ointment: Apply to the affected area 1 to 3 times daily; may cover with sterile bandage if needed

Adverse Reactions

See individual agents.

Contraindications

Hypersensitivity to bacitracin, polymyxin B, or any component of the formulation

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Ointment, External:

Double Antibiotic: Bacitracin 500 units and polymyxin B 10,000 units per g (1 ea [DSC], 14 g [DSC], 14.17 g [DSC], 14.2 g, 28 g [DSC], 28.35 g [DSC], 28.4 g)

Polysporin: Bacitracin 500 units and polymyxin B 10,000 units per g (1 ea, 14.2 g, 28.3 g)

Generic Equivalent Available: US

Yes

Pricing: US

Ointment (Polysporin External)

500-10000 units/g (per gram): $0.36

500-10000 units/g (per each): $0.26

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Administration: Adult

Topical: Clean affected area prior to application. Apply amount equal to the surface area of the tip of the finger. Do not use topical ointment in the eyes or over large areas of the body; avoid contact of tube tip with skin.

Administration: Pediatric

Topical: Cleanse affected area before application. Apply a small amount of product (an amount equal to the surface area of the tip of a finger); may be covered by a sterile bandage if necessary. Do not use topical ointment in the eyes or over large areas of the body; avoid contact of tube tip with skin.

Use: Labeled Indications

Topical infection prevention: Prevention of infection in minor cuts, scrapes, or burns

Metabolism/Transport Effects

None known.

Drug Interactions

There are no known significant interactions.

Pregnancy Considerations

Refer to individual monographs.

Breastfeeding Considerations

Refer to individual monographs.

Mechanism of Action

See individual agents.

Pharmacokinetics (Adult Data Unless Noted)

See individual agents.

Absorption: Insignificant from intact skin or mucous membrane

  1. Double Antibiotic Ointment (bacitracin zinc/polymyxin b sulfate) [prescribing information]. Livonia, MI: Rugby Laboratories; May 2018.
  2. Polysporin (bacitracin/polymyxin b) [prescribing information]. Skillman, NJ: Johnson & Johnson Consumer Products Company; December 2016.
Topic 103449 Version 125.0

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