Version May 2024
Ocular infections: Ophthalmic: Apply every 3 to 4 hours for 7 to 10 days.
There are no dosage adjustments provided in the manufacturer’s labeling.
There are no dosage adjustments provided in the manufacturer’s labeling.
Refer to adult dosing.
(For additional information see "Bacitracin, neomycin, and polymyxin B (ophthalmic): Pediatric drug information")
Conjunctivitis: Limited data available: Children and Adolescents: Ophthalmic: Apply 0.5 inch ribbon every 3 to 4 hours for acute infections, or 2 to 3 times per day for mild to moderate infections, for 7 to 10 days (Ref).
There are no dosage adjustments provided in the manufacturer’s labeling.
There are no dosage adjustments provided in the manufacturer’s labeling.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Frequency not defined.
Dermatologic: Reddening, allergic contact dermatitis
Local: Itching, failure to heal, swelling, irritation
Ophthalmic: Conjunctival edema
Miscellaneous: Anaphylaxis
Hypersensitivity to neomycin, polymyxin B, bacitracin, or any component of the formulation
Concerns related to adverse effects:
• Neomycin sensitization: Neomycin may cause cutaneous sensitization. Symptoms of neomycin sensitization include itching, reddening, edema, and failure to heal. Discontinuation of product and avoidance of similar products should be considered.
• Ocular effects: May retard corneal wound healing.
• Superinfection: Prolonged use may lead to overgrowth of nonsusceptible organisms, including fungi. If superinfection is suspected, institute appropriate alternative therapy.
Other warnings/precautions:
• Appropriate use: For topical ophthalmic use only. Do not introduce directly into anterior chamber of the eye. Inadvertent contamination of multiple-dose ophthalmic tube tip has caused bacterial keratitis.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Ointment, Ophthalmic:
Neo-Polycin: Bacitracin 400 units, neomycin 3.5 mg, and polymyxin B 10,000 units per g (3.5 g)
Generic: Bacitracin 400 units, neomycin 3.5 mg, and polymyxin B 10,000 units per g (3.5 g)
Yes
Ointment (Neo-Polycin Ophthalmic)
3.5-400-10000 (per gram): $15.01
Ointment (Neomycin-Bacitracin Zn-Polymyx Ophthalmic)
5-400-10000 (per gram): $16.27
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Ointment, Ophthalmic:
Diosporin: Bacitracin 500 units, neomycin 3.5 mg, and polymyxin B 10,000 units ([DSC])
For ophthalmic use only; not for injection into the eye. Avoid contamination of the tip of the ointment tube.
Ophthalmic: Wash hands prior to application; avoid contamination of the tip of the ointment tube
Ocular infections: Treatment of superficial external ocular infections (eg, conjunctivitis, keratitis, keratoconjunctivitis, blepharitis, blepharoconjunctivitis) caused by susceptible organisms.
None known.
There are no known significant interactions.
Refer to individual monographs.
Refer to individual monographs.
Bacitracin: Inhibits bacterial cell wall synthesis by preventing transfer of mucopeptides into the growing cell wall.
Neomycin: Interferes with bacterial protein synthesis by binding to 30S ribosomal subunits.
Polymyxin B: Binds to phospholipids, alters permeability, and damages the bacterial cytoplasmic membrane permitting leakage of intracellular constituents.
See individual agents.
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