Criteria A through C must be met: | |
A | The patient has daily periods of irrepressible need to sleep or daytime lapses into drowsiness or sleep. |
B | The presence of one or both of the following:
|
C | The symptoms and signs are not better explained by chronic insufficient sleep, a circadian rhythm sleep-wake disorder or other current sleep disorder, mental disorder, or medication/substance use or withdrawal. |
CSF: cerebrospinal fluid; MSLT: multiple sleep latency test; PSG: polysomnography; SOREMPs: sleep-onset rapid eye movement periods.
* Typical cataplexy is most strongly associated with narcolepsy type 1 (NT1). Although some patients with NT1/hypocretin deficiency may present with atypical cataplexy features, presentations that include only atypical cataplexy should raise a higher index of doubt regarding a diagnosis of NT1. Clinical judgment is required. Further guidance regarding distinguishing typical from atypical cataplexy is included in the Essential Features section of the International Classification of Sleep Disorders, third edition, text revision (ICSD-3-TR).
¶ Hypocretin-1 is also known as orexin-A.
Δ If hypocretin deficiency is verified, the diagnosis of NT1 should be made regardless of other comorbidities that could potentially be related to clinical symptoms, given the definitive nature of this finding.آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟