Comparison of pharmacokinetics for intravenous and subcutaneous immune globulin

Immune globulin pharmacokinetics for IVIG, SCIG, and fSCIG administration. The graph shows an illustration of the differences in the levels of IgG in the blood following IVIG (red dotted) and fSCIG infusion (blue solid), both given as a first infusion, compared with traditional SCIG (gray dashed), shown at a steady state over a 28-day time period. The differences in the pharmacokinetics of the three delivery modalities show the loss of the IVIG peak level with fSCIG, followed by a similar gradual decline in IgG levels over the dosing cycle. Traditional SCIG at steady state is characterized by very stable levels and a higher "trough" IgG level than IVIG or fSCIG. Levels of IgG on the Y-axis are given in g/L. Equivalent values in mg/dL are 0 to 2500 mg/dL.