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Betamethasone and salicylic acid (United States: Not available): Drug information

Betamethasone and salicylic acid (United States: Not available): Drug information
(For additional information see "Betamethasone and salicylic acid (United States: Not available): Patient drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: Canada
  • Diprosalic;
  • RATIO-Topisalic
Pharmacologic Category
  • Corticosteroid, Topical;
  • Keratolytic Agent
Dosing: Adult
Dermatoses

Dermatoses: Topical: Usual dose:

Lotion: Apply thin film to affected area of scalp twice daily (with maintenance therapy, some patients may respond adequately to less frequent application). If symptoms do not improve within a week, discontinue use and reassess patient.

Ointment: Apply thin film to affected area twice daily (with maintenance therapy, some patients may respond adequately to less frequent application). If symptoms do not improve within a week, discontinue use and reassess patient.

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in the manufacturer’s labeling.

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer’s labeling.

Dosing: Older Adult

Refer to adult dosing.

Dosing: Pediatric
Dermatoses

Dermatoses: Children and Adolescents: Topical: Refer to adult dosing.

Dosing: Kidney Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer’s labeling.

Dosing: Hepatic Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer’s labeling.

Adverse Reactions

See individual agents.

Contraindications

Hypersensitivity to betamethasone, salicylic acid or any component of the formulation; viral diseases including vaccinia, varicella, herpes simplex; fungal infections; tuberculosis of the skin.

Warnings/Precautions

Refer to individual agents.

Product Availability

Not available in the US

Dosage Forms Considerations

Each g of Diprosalic lotion/ointment contains 0.64 mg of betamethasone dipropionate which is equivalent to 0.5 mg of betamethasone; each g of lotion contains 20 mg of salicylic acid while each g of ointment contains 30 mg of salicylic acid

Generic Equivalent Available: US

No

Dosage Forms: Canada

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Lotion, External:

Diprosalic: Betamethasone dipropionate 0.05% and salicylic acid 2% ([DSC]) [contains edetate (edta) disodium, isopropyl alcohol]

Generic: Betamethasone dipropionate 0.05% and salicylic acid 2% (30 mL, 60 mL)

Ointment, External:

Diprosalic: Betamethasone dipropionate 0.05% and salicylic acid 3% (50 g)

Administration: Adult

Topical: Apply thin film of lotion to affected area of scalp or thin film of ointment to affected area once in the morning and night. Ointment should be massaged in gently. Do not cover treated area with occlusive dressing. Do not apply in or near the eyes. Avoid contact with mucous membranes, extensive lesions, the genital area and other orifices. Wash hands after application.

Administration: Pediatric

Topical: For external use only. Apply thin film of lotion to affected area of scalp or thin film of ointment to affected area once in the morning and night. Ointment should be massaged in gently. Do not cover treated area with occlusive dressing. Do not apply in or near the eyes. Avoid contact with mucous membranes, extensive lesions, the genital area, and other orifices. Wash hands after application.

Use: Labeled Indications

Note: Not approved in the US

Dermatoses: Topical management of subacute and chronic hyperkeratotic and dry dermatosis responsive to corticosteroid therapy.

Medication Safety Issues
Pediatric patients: High-risk medication:

KIDs List: Medium, high, and very high potency topical corticosteroids, when used in neonates and infants <1 year of age for diaper dermatitis, are identified on the Key Potentially Inappropriate Drugs in Pediatrics (KIDs) list; use should be avoided due to risk of adrenal suppression; systemic absorption is higher in pediatric patients than adults (strong recommendation; low quality of evidence) (PPA [Meyers 2020]).

KIDs List: Salicylates, when used in pediatric patients <18 years of age with suspicion of viral illness (influenza, chickenpox), are identified on the Key Potentially Inappropriate Drugs in Pediatrics (KIDs) list and should be used with caution due to risk of Reye syndrome (weak recommendation; very low quality of evidence) (PPA [Meyers 2020]).

Metabolism/Transport Effects

None known.

Drug Interactions

Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the Lexicomp drug interactions program by clicking on the “Launch drug interactions program” link above.

Calcipotriene: Salicylic Acid may diminish the therapeutic effect of Calcipotriene. Management: Monitor for reduced calcipotriene efficacy if combined with salicylic acid. Consider separating the administration of these agents by 10 to 12 hours to minimize the risk of this potential interaction. Risk C: Monitor therapy

CYP3A4 Inhibitors (Strong): May increase the serum concentration of Betamethasone (Topical). Risk C: Monitor therapy

Nirmatrelvir and Ritonavir: May increase the serum concentration of Corticosteroids (Topical). Risk C: Monitor therapy

Pregnancy Considerations

Refer to individual agents.

Breastfeeding Considerations

Refer to individual agents.

Monitoring Parameters

HPA axis suppression and adrenal insufficiency, especially in children; reassess if no improvement within 1 week of treatment.

Mechanism of Action

Refer to individual agents.

Pharmacokinetics (Adult Data Unless Noted)

Refer to individual agents.

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (AE) United Arab Emirates: Diprosalic | Salibet;
  • (AR) Argentina: Betasalic | Corticas salic | Diprosalic | Maxisalic | Salicort;
  • (AT) Austria: Diprosalic;
  • (BD) Bangladesh: Betamesal | Ecsota | Prosalic;
  • (BE) Belgium: Diprosalic;
  • (BF) Burkina Faso: Beta salic | Dermosalic | Diprosalic;
  • (BG) Bulgaria: Diprosalic;
  • (BR) Brazil: Dermosalic | Dipro as | Dipropionato de betametasona + acido salicili | Dipropionato de betametasona + acido salicilico | Diprosalic | Softderm;
  • (CI) Côte d'Ivoire: Beta salic | Skinosalic;
  • (CL) Chile: Diprosalic | Salicort;
  • (CO) Colombia: Betxol | Diprosalic;
  • (CZ) Czech Republic: Belosalic | Diprosalic;
  • (DE) Germany: Betadermic | Betamethason | Betamethason hexal comp | Betnesalic | Diprosalic | Soderm plus;
  • (DO) Dominican Republic: Betasalic | Diprosalic | Novasil s;
  • (EC) Ecuador: Diprosalic;
  • (EE) Estonia: Diprosalic | Sal-ekarzin;
  • (EG) Egypt: Betasalic | Betaval s | Betnosal | Diprosalic | Kerella | Salibet;
  • (ES) Spain: Diprosalic;
  • (ET) Ethiopia: Beprosalic | Betacylic;
  • (FI) Finland: Diprosalic;
  • (FR) France: Betnesalic | Diprosalic;
  • (GB) United Kingdom: Diprosalic;
  • (GR) Greece: Propiosalic;
  • (HK) Hong Kong: Aprosalic | Beprosalic | Beta salic | Betasal | Betasalic | Betnesalic | Diprosalic | Vick prosalic;
  • (HR) Croatia: Belosalic | Diprosalic;
  • (ID) Indonesia: Beprosalic | Diprosalic;
  • (IE) Ireland: Diprosalic;
  • (IL) Israel: Diprosalic;
  • (IN) India: Betasalic | Betnovate s | Betsalic | Camiderm-s | Cortisal | Dibederm-s | Diprovate mf | Dipsalic | Lupiderm-s | Misalic | Prosalic | Provate-s | Salisone | Saltopic | Sternon s | Sternon-sf | Trivate mf;
  • (IQ) Iraq: Salisone;
  • (IT) Italy: Diprosalic;
  • (JO) Jordan: Beprosalic | Diprosalic | Salibet;
  • (KE) Kenya: Bentosal | Betason s | Dawasalic | Diprosalic | Entezma | Mediven s;
  • (KW) Kuwait: Diprosalic | Salibet;
  • (LB) Lebanon: Diprosalic;
  • (LU) Luxembourg: Betadermic | Diprosalic;
  • (MA) Morocco: Diprosalic | Skinosalic;
  • (MX) Mexico: Diprosalic;
  • (MY) Malaysia: Beprosalic | Betacyclic | Betamethasone SA | Dermal SA | Diprosalic | Epiklin;
  • (NG) Nigeria: Saffrovate s;
  • (NL) Netherlands: Diprosalic;
  • (NO) Norway: Diprosalic;
  • (NZ) New Zealand: Diprosalic;
  • (PE) Peru: Diprosalic;
  • (PH) Philippines: Beprosalic | Diprosalic;
  • (PK) Pakistan: Austasalic | Beprosalic | Betacline s | Betamet s | Betasalic | Betasaly | Betasol s | Biosone sa | Corbesalate | Cylic | Dimed s | Diprocort s | Diprokalic | Diprosalic | Dipsal | Encore s | Eponix s | Novasalic | Proderm s | Provate-s | Saldio | Salibet | Saloderm | Valisone s;
  • (PL) Poland: Bedicort salic | Belosalic | Diprosalic;
  • (PT) Portugal: Dibetop q | Diprosalic | Psodermil;
  • (PY) Paraguay: Betasalic | Crinexalic | Dexacort plus | Diprosalic | Hexoderm salic;
  • (QA) Qatar: Diprosalic;
  • (RO) Romania: Belosalic | Diprosalic;
  • (RU) Russian Federation: Akriderm sk | Belosalic | Belosalic lotion | Betaderm a | Betnovate s | Diprosalic | Diprosalic lotion | Rederm;
  • (SA) Saudi Arabia: Betasal | Defosalic | Diprosalic | Salibet;
  • (SE) Sweden: Diprosalic;
  • (SG) Singapore: Beprosalic | Betacylic | Betosalic | Diprosalic;
  • (SI) Slovenia: Belosalic | Diprosalic | Kuterid salicil;
  • (SK) Slovakia: Belosalic | Diprosalic;
  • (TH) Thailand: Beta-s | Betasalic | Betosalic | Diprosalic | Epiklin | Mecylic;
  • (TN) Tunisia: Betasalic | Dermosalic | Diprosalic;
  • (TR) Turkey: Belosalic;
  • (TW) Taiwan: Besalic | Betame | Betasalic | Betasay | Diprosalic | Probisalic | Propisalic | Salic | Salisone | Songi;
  • (UA) Ukraine: Belosalic | Belosalic lotion | Betasalic | Dermabin | Diprosalic;
  • (UG) Uganda: Diprosalic | Mediven s;
  • (UY) Uruguay: Diprosalic;
  • (VE) Venezuela, Bolivarian Republic of: Diprosalic | Propiosalic;
  • (VN) Viet Nam: Asosalic | Besalicyd | Crederm | Dibetalic | Inozium | Lotusalic | Prozalic;
  • (ZA) South Africa: Diprosalic;
  • (ZM) Zambia: Beprosalic | Epiklin
  1. Diprosalic (betamethasone dipropionate/salicylic acid) [product monograph]. Kirkland, Quebec, Canada: Organon Canada Inc; April 2021.
  2. Meyers RS, Thackray J, Matson KL, et al. Key Potentially Inappropriate Drugs in Pediatrics: The KIDs List. J Pediatr Pharmacol Ther. 2020;25(3):175-191. [PubMed 32265601]
Topic 104416 Version 59.0

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