Version July 2025
| US trade name (manufacturer) | Progestin (mg)* | Estrogen (micrograms)¶ |
| Depo-Provera intramuscular (Pfizer) | Medroxyprogesterone acetate (150 mg/mL) | None |
| Depo-SubQ Provera 104 subcutaneous (Pfizer) | Medroxyprogesterone acetate (104 mg/0.65 mL) | None |
| Liletta 52 mg intrauterine device (Actavis) | Levonorgestrel (releases 0.0186 mg/day, decreasing to approximately 0.0163 mg/day at 1 year, then decreasing to approximately 0.0143 mg/day at 2 years, and 0.0126 mg/day at 3 years) | None |
| Mirena 52 mg intrauterine device (Bayer) | Levonorgestrel (releases approximately 0.02 mg/day, decreasing progressively to 0.01 mg/day by 5 years)Δ | None |
| Skyla 13.5 mg intrauterine device (Bayer) | Levonorgestrel (releases 0.014 mg/day, decreasing to approximately 0.01 mg/day after 60 days, then decreasing to approximately 0.005 mg/day after 3 years) | None |
| Nexplanon 68 mg subdermal implant (Organon)◊ | Etonogestrel (releases 0.06 to 0.07 mg/day in weeks 5 to 6, decreasing to approximately 0.035 to 0.045 mg/day by 1 year, then decreasing to approximately 0.03 to 0.04 mg/day by year 2, and then to 0.025 to 0.03 mg/day by end of year 3) | None |
* Different progestins are not equivalent on a milligram basis.
¶ Ethinyl estradiol and mestranol are not equivalent on a milligram basis; the results of some studies indicate that 30 to 35 mcg of ethinyl estradiol is equivalent to 50 mcg of mestranol.
Δ Decreases to 0.01 mg/day by 5 years. Do not leave same system in place for >5 years.
◊ Also contains radiopaque (barium sulfate 15 mg).Adapted with special permission from The Medical Letter on Drugs and Therapeutics, September 14, 2015; Vol. 57 (1477):e133-e134. www.medicalletter.org.
Additional data from: