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خرید پکیج

تعداد آیتم قابل مشاهده باقیمانده : 3 مورد

Conditions affecting antidiuretic hormone release and action in children

Conditions affecting antidiuretic hormone release and action in children

Name of disorder	Mechanism	Cause(s)
Conditions with a decrease in urinary volume
Syndrome of inappropriate ADH secretion (SIADH)	Nonphysiologic or inappropriate ADH release	Postoperative state CNS disease – Meningitis, brain tumors, head injury Pulmonary disease – Pneumonia, bronchiolitis, asthma Immobilization Drugs Antidepressants (eg, SSRIs) Antipsychotics (eg, haloperidol) Seizure medications (eg, carbamazepine) Chemotherapeutic agents (eg, vincristine, cisplatin, vinblastine) Opiates Response to pain, stress, or anxiety
"Hereditary" SIADH	Enhanced renal ADH receptor response	Gain-of-function variants in the renal vasopressin 2 receptor gene
Conditions with an increase in urinary volume
Arginine vasopressin deficiency (previously called central diabetes insipidus)	Impaired ADH release	CNS tumors (eg, craniopharyngioma) Congenital brain abnormalities (eg, septo-optic dysplasia) Brain trauma or injury (eg, complication of brain surgery) Genetic diseases Anorexia nervosa
Arginine vasopressin resistance (previously called nephrogenic diabetes insipidus)	Impaired renal ADH receptor response	Congenital disorders (eg, loss-of-function variant in renal vasopressin 2 receptor gene, renal tubulopathy [Bartter syndrome]) Drugs (eg, lithium toxicity, foscarnet, ifosfamide) Kidney disorders (eg, bilateral urinary tract obstruction, sickle cell nephropathy)

ADH: antidiuretic hormone (also known as arginine vasopressin); CNS: central nervous system; SIADH: syndrome of inappropriate antidiuretic hormone secretion; SSRI: selective serotonin release inhibitors.

Graphic 104673 Version 3.0

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