International Society for Human and Animal Mycology (ISHAM) working group diagnostic criteria for allergic bronchopulmonary aspergillosis

Predisposing conditions (one must be present)*:

Asthma

Cystic fibrosis

Obligatory criteria (both must be present):

Serum IgE levels against Aspergillus fumigatus (>0.35 kU/L) or Aspergillus skin test positivity.

Elevated total IgE concentration (typically >1000 IU/mL, but if the patient meets all other criteria, an IgE value <1000 IU/mL may be acceptable, especially if A. fumigatus-specific IgG levels are >27 mg/L)

Other criteria (at least two must be present):

Precipitating serum antibodies to A. fumigatus or elevated serum Aspergillus IgG by immunoassay (>27 mg/L)

Radiographic pulmonary opacities consistent with ABPA

Total eosinophil count >500 cells/microL in glucocorticoid-naïve patients (may be historical)

IgE: immunoglobulin E; ABPA: Allergic bronchopulmonary aspergillosis.
* Rarely, ABPA is identified in the absence of asthma or cystic fibrosis. COPD and post-tuberculous fibrocavitary disease may be predisposing conditions.

References:

Agarwal R, Chakrabarti A, Shah A, et al. Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria. Clin Exp Allergy 2013; 43:850.
Agarwal R, Sehgal IS, Dhooria S, Aggarwal AN. Developments in the diagnosis and treatment of allergic bronchopulmonary aspergillosis. Expert Rev Respir Med 2016; 10:1317.

Graphic 104812 Version 3.0

خرید پکیج

International Society for Human and Animal Mycology (ISHAM) working group diagnostic criteria for allergic bronchopulmonary aspergillosis