Dynamic International Prognostic Scoring System (DIPSS) and DIPSS Plus for primary myelofibrosis

DIPSS score

The DIPSS score assigns points for the following five variables:

Age >65 years: 1 point
Leukocyte count >25,000/microL (>25 x 10⁹/L): 1 point
Hemoglobin <10 g/dL (<100 g/L): 2 points
Circulating blast cells ≥1%: 1 point
Constitutional symptoms*: 1 point

The resulting score is interpreted as follows:

0 points – low risk
1 to 2 points – intermediate-1 risk
3 to 4 points – intermediate-2 risk
5 to 6 points – high risk

DIPSS Plus score

The DIPSS Plus score assigns points for the following variables:

DIPSS low risk: 0 points
DIPSS intermediate-1 risk: 1 point
DIPSS intermediate-2 risk: 2 points
DIPSS high risk: 3 points
Unfavorable karyotype^¶: 1 point
Platelet count <100,000/microL (<100 x 10⁹/L): 1 point
Anemia requiring transfusion: 1 point

The resulting score is interpreted as follows:

0 points – low risk
1 point – intermediate-1 risk
2 to 3 points – intermediate-2 risk
4 to 6 points – high risk

PMF: primary myelofibrosis; DIPSS: Dynamic International Prognostic Scoring System.
* Constitutional symptoms include: Weight loss >10% of the baseline value in the year preceding PMF diagnosis, and/or unexplained fever or excessive sweats persisting for more than one month.
¶ Unfavorable karyotype includes: Complex karyotype or one or two abnormalities that include +8, –7/7q–, i(17q), –5/5q–, 12p–, inv(3), or 11q23.

Source: Gangat N, Caramazza D, Vaidya R, et al. DIPSS plus: a refined Dynamic International Prognostic Scoring System for primary myelofibrosis that incorporates prognostic information from karyotype, platelet count, and transfusion status. J Clin Oncol 2011; 29:392.

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Dynamic International Prognostic Scoring System (DIPSS) and DIPSS Plus for primary myelofibrosis