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Causes of systolic, diastolic, and continuous murmurs in infants and children

Causes of systolic, diastolic, and continuous murmurs in infants and children
Systolic murmurs:
Stenotic semilunar valves: Valvar PS or AS
Stenotic intracardiac lesions: Subvalvar PS or AS, double chamber right ventricle
Stenotic intravascular lesions: Supravalvar PS or AS, CoA, PPS
Regurgitant AV valves: MR, TR
Increased flow across normal semilunar valves: Tachycardia, anemia, "relative PS" associated with right ventricular volume overload (eg, ASD)
Left-to-right shunt across VSD
Normal cardiac anatomy (innocent murmur)
Diastolic murmurs:
Regurgitant flow across semilunar valves: PR or AR
Turbulent flow across AV valves: MS or TS
Increased flow across normal AV valves ("relative AV valve stenosis"): ASDs, VSDs, or PDAs with high degree of left-to-right shunting [Qp:Qs >2]; severe MR or TR with increased flow across the affected valve in diastole
Continuous murmurs:
Connection between systemic and pulmonary circulation: PDA, surgically created systemic-pulmonary artery shunts, aortopulmonary collateral artery, aortopulmonary window, anomalous left coronary artery arising from the main pulmonary artery
Connection between systemic artery and systemic vein: AVM
Connection between systemic artery and cardiac chambers: Coronary arteriovenous fistula, ruptured sinus of Valsalva aneurysm
Disturbed flow in arteries: Collateral flow associated with severe coarctation of the aorta
Disturbed flow in veins: Venous hum
PS: pulmonary stenosis; AS: aortic stenosis; CoA: coarctation of the aorta; PPS: peripheral pulmonary stenosis; AV: atrioventricular; MR: mitral regurgitation; TR: tricuspid regurgitation; ASD: atrial septal defect; VSD: ventricular septal defect; PR: pulmonary regurgitation; AR: aortic regurgitation; MS: mitral stenosis; TS: tricuspid stenosis; PDA: patent ductus arteriosus; Qp:Qs: ratio of pulmonary to systemic blood flow; AVM: arteriovenous malformation.
Adapted from: Geggel RL. The cardiac examination. In: Comprehensive Pediatric Hospital Medicine, Zaoutis LB, Chiang VW (Eds), Philadelphia: Mosby, 2007. p.513.
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