Comparison of the three major types of leg ulcers

	Venous	Arterial	Neuropathic
History	Prior deep venous thrombosis, stroke, miscarriages Obesity, multiple pregnancies Pain upon prolonged standing	Cigarette smoking Diabetes Dyslipidemia Intermittent claudication	Diabetes Other causes of peripheral neuropathy
Location	Gaiter distribution Malleolar regions (medial > lateral)	Pressure sites Distal points (toes)	Pressure sites
Pain	Mild to moderate	Severe	Painless
Morphology	Irregular borders Shallow	Necrotic eschar Punched out	Punched out
Surrounding skin	Pigmentation secondary to hemosiderin Lipodermatosclerosis	Shiny atrophic skin with hair loss	Thick callus surrounding ulcer
Other physical examination findings	Varicosities Peripheral edema Stasis dermatitis	Weak/absent peripheral pulses Prolonged capillary refilling time (>3 to 4 seconds) Pallor on leg elevation (45° for 1 min)	Peripheral neuropathy with decreased sensation
Relevant studies	Duplex ultrasonography	Ankle-brachial index Computed tomography angiography (CTA) Magnetic resonance angiography (MRA)

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