Initial therapy | |||
Total thyroidectomy and RAI ablation | Total thyroidectomy without RAI ablation | Lobectomy | |
Excellent response | Nonstimulated Tg level <0.2 ng/mL* or stimulated Tg level <1 ng/mL* and undetectable TgAb and negative imaging | Nonstimulated Tg level <0.2 ng/mL* or stimulated Tg level <2 ng/mL* and undetectable TgAb and negative imaging | Stable, nonstimulated Tg level <30 ng/mL* and undetectable TgAb and negative imaging |
Biochemical incomplete response | Nonstimulated Tg level >1 ng/mL* or stimulated Tg level >10 ng/mL* or increasing TgAb levels and negative imaging | Nonstimulated Tg level >5 ng/mL* or stimulated Tg level >10 ng/mL* or increasing Tg values over time with similar TSH levels or increasing TgAb levels and negative imaging | Nonstimulated Tg level >30 ng/mL* or increasing Tg level values over time with similar TSH levels or increasing TgAb levels and negative imaging |
Structural incomplete response | Structural or functional evidence of disease regardless of Tg or TgAb | Structural or functional evidence of disease regardless of Tg or TgAb | Structural or functional evidence of disease regardless of Tg or TgAb |
Indeterminate response | Nonspecific findings on imaging studies or faint uptake in thyroid bed on RAI scanning or nonstimulated Tg level 0.2-1 ng/mL* or stimulated Tg level 1-10 ng/mL* or TgAb levels stable or declining in the absence of structural or functional disease | Nonspecific findings on imaging studies or faint uptake in thyroid bed on RAI scanning or nonstimulated Tg level 0.2-5 ng/mL* or stimulated Tg level 2-10 ng/mL* or TgAb levels stable or declining in the absence of structural or functional disease | Nonspecific findings on imaging studies or TgAb levels stable or declining in the absence of structural or functional disease |
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