Hyaluronidase-facilitated subcutaneous immune globulin (HyQvia): Initial treatment interval/dose ramp-up schedule

Week	Infusion number	Dose interval	Example for 30 grams per four weeks
1	First infusion	One-week dose	7.5 grams
2	Second infusion	Two-week dose	15 grams
3	No infusion
4	Third infusion	Three-week dose	22.5 grams
5	No infusion
6	No infusion
7	Fourth infusion (if required)	Four-week dose	30 grams

For patients switching from intravenous immune globulin (human) (IVIG) treatment:

After the initial dose ramp-up, administer HyQvia at the same dose and frequency as the previous intravenous treatment.

For patients naïve to immune globulin treatment or switching from immune globulin subcutaneous (human) (SCIG):

After initial ramp-up, administer HyQvia at 300 to 600 mg/kg at three- to four-week intervals.

Reproduced from: HYQVIA. US Food & Drug Administration (FDA) approved product information. Revised September, 2014. US National Library of Medicine. Available online at www.dailymed.nlm.nih.gov (Accessed December 3, 2015).

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Hyaluronidase-facilitated subcutaneous immune globulin (HyQvia): Initial treatment interval/dose ramp-up schedule