Opioid withdrawal syndrome

Drug	Time course of opioid withdrawal symptoms following last dose
Drug	Onset	Peak	Nearly complete
Fentanyl (IV)	3 to 5 hours	8 to 12 hours	4 to 5 days
Heroin (diamorphine) (IV or inhaled)	8 to 12 hours	36 to 72 hours	7 to 10 days
Methadone	24 to 72 hours	4 to 6 days	14 to 21 days

Heroin (diamorphine) time course of abstinence symptoms approximates those for oxycodone, hydrocodone, codeine, and morphine.

IV: intravenous.

Graphic 105766 Version 2.0

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