Advantages and disadvantages of oral versus IV iron

	Advantages	Disadvantages
Oral iron	Effective for most patients Extremely low risk of serious adverse events Initial costs very low	Gastrointestinal side effects are common Adherence may be low May be inadequate for severe or ongoing blood loss May require administration for several months Total costs may be higher
IV iron	Effective for most patients More rapid correction of anemia and resolution of symptoms Ability to administer large doses (up to 1000 mg elemental iron) in a single infusion Adherence is assured No gastrointestinal side effects	Requires monitored intravenous infusion Rare cases of allergic or infusion reactions Requires equipment and personnel to treat allergic or infusion reactions Initial costs may be higher

Refer to UpToDate for further details and for a separate table on measures to improve absorption and tolerability of oral iron. Advantages, disadvantages, costs, and burdens for any individual patient may depend on a number of factors.

IV: intravenous.

Graphic 106070 Version 3.0

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Advantages and disadvantages of oral versus IV iron