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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Antifungal activity of echinocandins against Candida and Aspergillus spp

Antifungal activity of echinocandins against Candida and Aspergillus spp
Antifungal agent MIC (mcg/mL) CLSI
50% 90% % Resistant % Nonwild-type
Candida albicans (n = 835)
Anidulafungin 0.015 0.03 0.0 0.2
Caspofungin 0.015 0.03 0.1 --
Micafungin 0.015 0.03 0.1 0.4
Candida glabrata (n = 374)
Anidulafungin 0.06 0.12 3.2 3.2
Caspofungin 0.03 0.06 2.1 --
Micafungin 0.015 0.03 2.4 6.7
Candida parapsilosis (n = 329)
Anidulafungin 2 2 0 0
Caspofungin 0.25 0.5 0 --
Micafungin 1 1 0 0
Candida tropicalis (n = 196)
Anidulafungin 0.03 0.06 1 2
Caspofungin 0.015 0.06 1 --
Micafungin 0.03 0.06 1 3.6
Candida krusei (n = 77)
Anidulafungin 0.06 0.12 0 0
Caspofungin 0.12 0.25 0 --
Micafungin 0.06 0.12 0 0
Candida dubliniensis (n = 93)
Anidulafungin 0.03 0.12 -- 0
Caspofungin 0.03 0.03 -- 0
Micafungin 0.03 0.03 -- 0
Cryptococcus neoforams var. grubii (n = 73)
Anidulafungin >4 >4 -- --
Caspofungin >4 >4 -- --
Micafungin >4 >4 -- --
Aspergillus fumigatus (n = 183)
Anidulafungin 0.015 0.03 -- 0
Caspofungin 0.015 0.03 -- 0
Micafungin 0.015 0.03 -- 0
Aspergillus section Flavi (n = 45)
Anidulafungin ≤0.008 0.015 -- 0
Caspofungin ≤0.008 0.015 -- 0
Micafungin 0.015 0.03 -- 0
MIC: minimum inhibitory concentration; CLSI: Clinical Laboratory Standards Institute breakpoints based on M60 standard.
*Nonwild-type based on epidemiologic cut-off value from CLSI M59 document.
Data from: Pfaller, MA, Carvalhaes C, Messer SA, et al. Activity of a Long-Acting Echinocandin, Rezafungin, and Comparator Antifungal Agents Tested against Contemporary Invasive Fungal Isolates (SENTRY Program, 2016 to 2018). Antimicrob Agent Chemother 2020; 64:e00099. Available at: https://aac.asm.org/content/64/4/e00099-20.long. Copyright © 2020 The Authors. Reproduced under the terms of the Creative Commons Attribution License 4.0.
Graphic 107624 Version 2.0

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