Algorithmic approach to treatment of locally advanced or locally recurrent cholangiocarcinoma

PDT: photodynamic therapy; FU: fluorouracil; CRT: chemoradiotherapy; Gy: Gray; BED: biologic equivalent dose; SBRT: stereotactic body radiation therapy.
* The role of orthotopic liver transplantation after neoadjuvant therapy for locally advanced, initially unresectable disease is controversial; refer to UpToDate text.
¶ Solitary site of unresectable disease, able to tolerate chemoradiotherapy.