Infant age | Dosing of nevirapine (NVP) | Dosing of zidovudine (AZT) |
Birth to 6 weeks | ||
Birth weight 2000 to 2499 grams* | 10 mg once daily (1 mL of syrup once daily) | 10 mg twice daily (1 mL of syrup twice daily) |
Birth weight ≥2500 grams | 15 mg once daily (1.5 mL of syrup once daily) | 15 mg twice daily (1.5 mL of syrup twice daily) |
>6 weeks to 12 weeks | ||
20 mg once daily (2 mL of syrup once daily or half a 50 mg tablet once daily) | 60 mg twice daily¶ (6 mL of syrup twice daily or a 60 mg tablet twice daily) |
* For infants older than 35 weeks gestational age who weigh <2000 grams, the suggested doses are: NVP 2 mg/kg per dose once daily and AZT 4 mg/kg per dose twice daily. Premature infants younger than 35 weeks of gestational age should be dosed using expert guidance.
¶ The prophylaxis dose for zidovudine in these infants has not been established; the treatment dose is recommended.