Infant antiretroviral prophylaxis dosing

Infant age	Dosing of nevirapine (NVP)	Dosing of zidovudine (AZT)
Birth to 6 weeks
Birth weight 2000 to 2499 grams*	10 mg once daily (1 mL of syrup once daily)	10 mg twice daily (1 mL of syrup twice daily)
Birth weight ≥2500 grams	15 mg once daily (1.5 mL of syrup once daily)	15 mg twice daily (1.5 mL of syrup twice daily)
>6 weeks to 12 weeks
	20 mg once daily (2 mL of syrup once daily or half a 50 mg tablet once daily)	60 mg twice daily^¶ (6 mL of syrup twice daily or a 60 mg tablet twice daily)

* For infants older than 35 weeks gestational age who weigh <2000 grams, the suggested doses are: NVP 2 mg/kg per dose once daily and AZT 4 mg/kg per dose twice daily. Premature infants younger than 35 weeks of gestational age should be dosed using expert guidance.
¶ The prophylaxis dose for zidovudine in these infants has not been established; the treatment dose is recommended.

Reprinted from: Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: Recommendations for a public health approach, 2nd edition, World Health Organization, Annex 11, p. 388, Copyright © 2016. Available from: https://apps.who.int/iris/bitstream/handle/10665/208825/9789241549684_eng.pdf?sequence=1 (Accessed on December 10, 2021).

Graphic 108738 Version 2.0

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Infant antiretroviral prophylaxis dosing