Ras pathway

Schematic diagram showing ligand-stimulated Ras activation, the Ras-Erk pathway, and the gene mutations found to date contributing to the neuro-cardio-facio-cutaneous congenital disorders and JMML.

NL/MGCL: Noonan-like/multiple giant cell lesion; CFC: Cardia-facio-cutaneous; JMML: juvenile myelomonocytic leukemia.

Modified from: Chan RJ, Cooper T, Kratz CP, et al. Juvenile myelomonocytic leukemia: a report from the 2nd International JMML Symposium. Leuk Res 2009; 33:355.

Graphic 108739 Version 1.0

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Ras pathway