Log-linear effect of genetically and pharmacologically mediated lower LDL-C

(Panel A) Boxes represent proportional CHD risk reduction (1 – OR) for each exposure allele plotted against the absolute magnitude of lower LDL-C associated with that allele (top line), or the proportional CHD risk reduction (1 – RR) for each trial plotted against the mean absolute difference in LDL-C between treatment arms at one-year follow-up for that trial (bottom line). Vertical lines represent one SE above and below point estimate of proportional risk reduction. SNPs and trials are plotted in order of increasing absolute magnitude of exposure to lower LDL-C. The lines (which are forced to pass through the origin) represent the increase in proportional risk reduction of CHD per unit exposure to lower LDL-C.
(Panel B) Boxes represent the OR for the association between the exposure allele (defined as the allele associated with lower LDL-C) and risk of CHD for each polymorphism or genetic LDL-C score. Bars represent 95% CI. Effect estimates and standard errors are adjusted for a standard decrement of 10 mg/dL (0.25 mmol/L) lower LDL-C using the usual ratio of effect estimates method.