Distinguishing features between subcutaneous panniculitis-like T cell lymphoma and primary cutaneous gamma-delta T cell lymphoma

	SPTCL	PCGD-TCL
Immunophenotype	TCR-beta, CD4-, CD8+, CD56-	TCR-gamma-delta+, CD4-, CD8-, CD56±
Architecture	Subcutaneous	Subcutaneous and/or epidermal/dermal
Clinical features	Nodules and plaques, rarely ulceration, association with autoimmune disorders (20%)	Nodules and plaques, ulceration common
HPS	Uncommon (17%)	Common (50%)
Five-year survival	91% (without HPS), 46% (with HPS)	11%
Treatment	Systemic steroids	Systemic chemotherapy

SPTCL: subcutaneous panniculitis-like T cell lymphoma; PCGD-TCL: primary cutaneous gamma-delta T cell lymphoma; TCR: T cell receptor; HPS: hemophagocytic syndrome.

Adapted from: Willemze R, Jansen PM, Cerroni L, et al. Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group Study of 83 cases. Blood 2008; 111:838.

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خرید پکیج

Distinguishing features between subcutaneous panniculitis-like T cell lymphoma and primary cutaneous gamma-delta T cell lymphoma