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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
نسخه الکترونیک
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Physiologic effects of deep hypothermia

Physiologic effects of deep hypothermia
Bleeding diathesis
  • Decreased platelet count
    • Splanchnic sequestration of platelets
    • Partial activation of circulating platelets causing aggregation and adhesion
  • Slowing of enzymatic reactions in the coagulation cascade
  • Enhanced fibrinolysis as a consequence of vascular injury
  • Impairment of tissue factor activity
  • Inflammatory responses to CPB
  • Ischemia-reperfusion injury that further exacerbates coagulopathy
  • Disseminated intravascular coagulation may occur
Cardiovascular effects
  • Prolongation of PR interval and QRS complex on the ECG
  • Decreased heart rate
  • Decreased cardiac output
  • Vasoconstriction during cooling and hypothermia
  • Vasodilation during rewarming and reperfusion
Hyperglycemia due to:
  • Stress response
  • Glucocorticoid administration
  • Catecholamine administration
Changes in metabolic rate
  • Decreased metabolic rate and oxygen consumption during hypothermia
  • Increased metabolic rate during rewarming, particularly with shivering (mitigated by administration of neuromuscular blocking agents)
Decreased metabolism of drugs
Decreased anesthetic requirements
Leftward shift of the oxygen-hemoglobin dissociation curve, with increased binding affinity of hemoglobin to oxygen
CPB: cardiopulmonary bypass; ECG: electrocardiogram.
Graphic 109339 Version 2.0

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