Gene structure of the human major histocompatibility complex
Gene structure of the human major histocompatibility complex
Chromosome 6 and its cytogenetic bands are shown. The human MHC region, also referred to as the HLA region (pink), is located on the short arm at position p21.3. The classical MHC spans 3.6 megabases (Mb) and includes more than 200 genes. Some MHC class I, II, and III genes are shown schematically.
C4A: complement factor C4A; C4B: complement factor C4B; HLA: human leukocyte antigen; LMP: low-molecular-weight protein (proteasome subunit); LTA: lymphotoxin alpha; LTB: lymphotoxin beta; MHC: major histocompatibility complex; TAP: transporter associated with antigen processing; TAPBP: TAP binding protein; TNF: tumor necrosis factor-alpha.
Modified from: Murphy KM, Travers P, Walport R. Antigen presentation to T lymphocytes. In: Janeway's Immunobiology, 7th ed, Murphey KM, Travers P, Walport M (Eds), Garland Science, 2007.
