Rapid attainment of steady state with remifentanil

Simulation demonstrating plasma concentrations after administration of a bolus dose of remifentanil followed by an infusion, showing the rapid attainment of steady state when a bolus is used.

Ce: Effect site concentration.

Reproduced from: Ogura T, Egan TD. Opioid Agonists and Antagonists. In: Pharmacologyand Physiology for Anesthesia: Foundations and Clinical Application, Hemmings HC, Egan TD (Eds), Philadelphia, PA, Elsevier, 2013. Illustration used with the permission of Elsevier Inc. All rights reserved.

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Rapid attainment of steady state with remifentanil