Bolus front-end and back-end pharmacokinetics of opioids

Percent of peak effect-site concentration (Ce) after bolus dosing of different opioids.

Reproduced from: Ogura T, Egan TD. Opioid Agonists and Antagonists. In: Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application, Hemmings HC, Egan TD (Eds), Philadelphia, PA, Elsevier, 2013. Illustration used with the permission of Elsevier Inc. All rights reserved.

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