World Health Organization (WHO) classification of ependymomas

Location	Tumor classification	CNS WHO grade
Supratentorial	Supratentorial subependymoma	1
	Supratentorial ependymoma, ZFTA fusion-positive^*	2, 3
	Supratentorial ependymoma, YAP1 fusion-positive^*	2, 3
Infratentorial	Posterior fossa subependymoma	1
	Posterior fossa ependymoma, group PFA^*	2, 3
	Posterior fossa ependymoma, group PFB^*	2, 3
Spinal	Spinal subependymoma	1
	Myxopapillary ependymoma	2
	Spinal ependymoma	2, 3
	Spinal ependymoma, MYCN-amplified	NA

CNS: central nervous system; NA: not assigned; PFA: posterior fossa group A; PFB: posterior fossa group B; YAP1: Yes1-associated transcriptional regulator; ZFTA: zinc finger translocation-associated.

* For morphologically defined tumors.

Data from: WHO Classification of Tumours Editorial Board. Central nervous system tumours. Lyon (France): International Agency for Research on Cancer; 2021. (WHO classification of tumours series, 5^th ed.; vol. 6).

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World Health Organization (WHO) classification of ependymomas