Selected available factor IX products for patients with hemophilia B

Product name	Half-life (hours)*	Characteristics
Standard half-life products
AlphaNine SD	18^¶	Plasma-derived; solvent/detergent treated
BeneFIX	16 to 19	Recombinant
Ixinity	24^Δ	Recombinant
Mononine	23^¶	Plasma-derived; mAb purified
Rixubis	23 to 26	Recombinant
Longer-lasting products
Alprolix	54 to 90	Recombinant; Fc fusion
Idelvion	104^¶	Recombinant; albumin fusion
Rebinyn	103 to 115	Recombinant; glycoPEGylated

This table is intended as a guide for rapid identification of the product the patient is using and its characteristics. Refer to the product information and to UpToDate for the use of factor replacement in patients with hemophilia.

SD: solvent/detergent treated; mAb: monoclonal antibody.
* Half-lives are approximate. Half-lives are generally shorter for children than adults when assessed in pharmacokinetic studies. The half-life of factor IX products without modifications to extend half-life is considered to be approximately 24 hours. The half-life should be determined for the individual patient. Refer to product information and institutional guidelines for additional dosing and monitoring information.
¶ Adults only.
Δ 12 years and older.

Graphic 109839 Version 4.0

خرید پکیج

Selected available factor IX products for patients with hemophilia B